ACVR1C

ACVR1C
Identifiers
Aliases	ACVR1C, ACVRLK7, ALK7, activin A receptor type 1C
External IDs	OMIM: 608981; MGI: 2661081; HomoloGene: 26724; GeneCards: ACVR1C; OMA:ACVR1C - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	157,628,864 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	58,247,907 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; adipose tissue; ; secondary oocyte; ; endothelial cell; ; islet of Langerhans; ; subcutaneous adipose tissue; ; testicle; ; buccal mucosa cell; ; lactiferous gland; ; abdominal fat;
	Top expressed in
	brown adipose tissue; ; white adipose tissue; ; intercostal muscle; ; subcutaneous adipose tissue; ; Paneth cell; ; dorsal striatum; ; lumbar subsegment of spinal cord; ; substantia nigra; ; mammary gland; ; nucleus accumbens;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; activin receptor activity, type I; nucleotide binding; protein kinase activity; growth factor binding; metal ion binding; kinase activity; transmembrane receptor protein serine/threonine kinase activity; nodal binding; ATP binding; protein serine/threonine kinase activity; transforming growth factor beta-activated receptor activity; transforming growth factor beta receptor activity, type I; SMAD binding; activin binding;
Cellular component	integral component of membrane; membrane; plasma membrane; activin receptor complex; integral component of plasma membrane; receptor complex;
Biological process	response to dietary excess; cell differentiation; negative regulation of insulin secretion; phosphorylation; lipid storage; response to glucose; negative regulation of trophoblast cell migration; nodal signaling pathway; response to insulin; protein phosphorylation; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; transmembrane receptor protein serine/threonine kinase signaling pathway; apoptotic nuclear changes; negative regulation of chorionic trophoblast cell proliferation; apoptotic process; transforming growth factor beta receptor signaling pathway; pattern specification process; activin receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	130399
	269275
	ENSG00000123612
	ENSMUSG00000026834
	Q8NER5
	Q8K348
	NM_145259; NM_001111031; NM_001111032; NM_001111033
	NM_001033369; NM_001111030
	NP_001104501; NP_001104502; NP_001104503; NP_660302
	NP_001028541; NP_001104500
	Wikidata
View/Edit Human	View/Edit Mouse

The activin A receptor also known as ACVR1C or ALK-7 is a protein that in humans is encoded by the ACVR1C gene. ACVR1C is a type I receptor for the TGFB family of signaling molecules.

ACVR1C transduces signals of Nodal. Nodal binds to ACVR2B and then forms a complex with ACVR1C. These go on to recruit the R-SMADs SMAD2 or SMAD3.

Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD family transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors.