Disintegrin and metalloproteinase domain-containing protein 20 is an enzyme encoded by the ADAM20 gene in humans. It is a membrane disintegrin-metalloprotease that belongs to the ADAM family. It is exclusively expressed in the Testes and is similar to sperm cell-specific fertilins -alpha and -beta.
Its cDNA is tightly linked to marker SHGC-36001 on chromosome 14q24.1. ADAM20 is related to fertilin α (ADAM1A/B pseudogene), fertilin β (ADAM2), and fertilin γ (ADAM9). In humans, fertilin α has recently been deactivated so that ADAM20 may be the functional equivalent of fertilin α in humans.
