AIM2

AIM2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3RN2, 3RN5, 3VD8, 4O7Q
Identifiers
Aliases	AIM2, PYHIN4, absent in melanoma 2
External IDs	OMIM: 604578; MGI: 2686159; HomoloGene: 83226; GeneCards: AIM2; OMA:AIM2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	159,187,843 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	173,466,040 bp
RNA expression pattern
	Top expressed in
	lymph node; ; spleen; ; sperm; ; monocyte; ; appendix; ; superficial temporal artery; ; blood; ; pituitary gland; ; epithelium of nasopharynx; ; gonad;
	Top expressed in
	granulocyte; ; ventricular zone; ; thymus; ; left colon; ; embryo; ; subiculum; ; genital tubercle; ; embryo; ; lateral geniculate nucleus; ; medial geniculate nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein binding; identical protein binding; double-stranded DNA binding;
Cellular component	cytoplasm; AIM2 inflammasome complex; nucleus; nucleoplasm; mitochondrion; cytosol;
Biological process	positive regulation of cysteine-type endopeptidase activity; pyroptosis; cellular response to interferon-beta; immune system process; tumor necrosis factor-mediated signaling pathway; positive regulation of NF-kappaB transcription factor activity; immune response; positive regulation of interleukin-1 beta production; positive regulation of protein oligomerization; activation of innate immune response; inflammatory response; negative regulation of NF-kappaB transcription factor activity; positive regulation of defense response to virus by host; apoptotic process; innate immune response;
	Sources:Amigo / QuickGO
Orthologs
	9447
	383619
	ENSG00000163568
	ENSMUSG00000037860
	O14862
	Q91VJ1
	NM_004833; NM_001348247
	NM_001013779
	NP_004824; NP_001335176
	NP_001013801
	Wikidata
View/Edit Human	View/Edit Mouse

Interferon-inducible protein AIM2 also known as absent in melanoma 2 or simply AIM2 is a protein that in humans is encoded by the AIM2 gene.

AIM2 is a cytoplasmic sensor found in hematopoietic cells that recognizes the presence of double-stranded DNA (dsDNA) of microbial or host cellular origin. AIM2-like receptor (ALR) family was founded on AIM2 and now consists of four members in human genome. Activated AIM2 recruits apoptosis-associated speck-like protein containing a CARD (ASC), resulting in caspase-1 binding, and forming of AIM2 inflammasome. This signaling contributes to the defense against bacterial and viral DNA. The AIM2 inflammasome can also be an integral component of the AIM2-PANoptosome to drive PANoptosis.