AKNA

AKNA
Identifiers
Aliases	AKNA, AT-hook transcription factor
External IDs	OMIM: 605729; MGI: 2140340; HomoloGene: 49947; GeneCards: AKNA; OMA:AKNA - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	114,394,405 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	63,403,354 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; blood; ; bone marrow cells; ; spleen; ; appendix; ; monocyte; ; lymph node; ; right uterine tube; ; epithelium of colon; ; mucosa of ileum;
	Top expressed in
	granulocyte; ; lymph node; ; mesenteric lymph nodes; ; spleen; ; blood; ; Rostral migratory stream; ; thymus; ; bone marrow; ; tibiofemoral joint; ; subcutaneous adipose tissue;
	More reference expression data
	n/a
Gene ontology
Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	membrane; nucleus; fibrillar center; nucleoplasm; centrosome; cytosol; intracellular membrane-bounded organelle; centriole; microtubule; cytoplasm; cytoskeleton;
Biological process	regulation of transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; transcription, DNA-templated; transcription by RNA polymerase II; epithelial to mesenchymal transition; neuroblast division in subventricular zone; regulation of inflammatory response; delamination; neuroblast delamination; nervous system development;
	Sources:Amigo / QuickGO
Orthologs
	80709
	100182
	ENSG00000106948
	ENSMUSG00000039158
	Q7Z591
	Q80VW7
	NM_030767; NM_001317950; NM_001317952
	NM_001045514; NM_001305432
	NP_001304879; NP_001304881; NP_110394
	NP_001038979; NP_001292361
	Wikidata
View/Edit Human	View/Edit Mouse

AKNA is a protein that in humans is encoded by the AKNA gene. The protein is an AT-hook transcription factor which contains an AT-hook binding motif. The protein is expressed as different isoforms. AKNA is known to upregulate expression of the receptor CD40 and its ligand CD40L/CD154.

AKNA is an essential part in the construction, organization, and proliferation of the centrosomal microtubules in order to maintain the neural stem cells during the process of neurogenesis. Due to these functions AKNA plays in the centrosomal microtubules it also has an active role in delamination during the formation of the subventricular zone, and the regulation of the amount of access provided to cells in this zone. Furthermore, because of AKNA's role in the centrosomal microtubules it also plays a part in the management of the modification of epithelial cells losing their polarity and attachment, and transforming into the mobile mesenchymal stem cells, epithelial-mesenchymal transition (EMT). This occurs because the alongside the increase in centrosomal microtubules both nucleation factors and minus end stabilizers are also increasing, causing the apical endfoot to have its constriction regulated because this affects the microtubules found at adherens junctions.