AM-679 (FLAP inhibitor)

AM-679 (FLAP inhibitor)
Identifiers
	IUPAC name 3-(5-[(S)-1-acetyl-2,3-dihydro-1H-indol-2-ylmethoxy]-3-t-butylsulfanyl-1-[4-(5-methoxypyrimidin-2-yl)benzyl]-1H-indol-2-yl)-2,2-dimethylpropionic acid;
CAS Number	1206880-66-1;
PubChem CID	44627267;
ChemSpider	25991470 ;
UNII	65KJ8P7M9D;
Chemical and physical data
Formula	C40H44N4O5S
Molar mass	692.88 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES n5cc(OC)cnc5-c6ccc(cc6)Cn(c1CC(C)(C)C(=O)O)c4ccc(cc4c1SC(C)(C)C)OCC3Cc2ccccc2N3C(=O)C;
	InChI InChI=1S/C39H42N4O5S/c1-24(44)43-28(18-27-10-8-9-11-32(27)43)23-48-29-16-17-33-31(19-29)34(49-38(2,3)4)35(39(5,6)37(45)46)42(33)22-25-12-14-26(15-13-25)36-40-20-30(47-7)21-41-36/h8-17,19-21,28H,18,22-23H2,1-7H3,(H,45,46)/t28-/m0/s1 ; Key:XTSOSRWDZSKOSB-NDEPHWFRSA-N ;
	(verify)

AM-679 is a drug which acts as a selective inhibitor of 5-Lipoxygenase-activating protein (FLAP). This protein is involved in the production of cysteinyl leukotrienes which are involved in inflammation, and AM-679 has anti-inflammatory effects in animal studies.

Identifiers

IUPAC name 3-(5-[(S)-1-acetyl-2,3-dihydro-1H-indol-2-ylmethoxy]-3-t-butylsulfanyl-1-[4-(5-methoxypyrimidin-2-yl)benzyl]-1H-indol-2-yl)-2,2-dimethylpropionic acid
CAS Number	1206880-66-1
PubChem CID	44627267
ChemSpider	25991470^Y
UNII	65KJ8P7M9D
Chemical and physical data
Formula	C₄₀H₄₄N₄O₅S
Molar mass	692.88 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES n5cc(OC)cnc5-c6ccc(cc6)Cn(c1CC(C)(C)C(=O)O)c4ccc(cc4c1SC(C)(C)C)OCC3Cc2ccccc2N3C(=O)C
InChI InChI=1S/C39H42N4O5S/c1-24(44)43-28(18-27-10-8-9-11-32(27)43)23-48-29-16-17-33-31(19-29)34(49-38(2,3)4)35(39(5,6)37(45)46)42(33)22-25-12-14-26(15-13-25)36-40-20-30(47-7)21-41-36/h8-17,19-21,28H,18,22-23H2,1-7H3,(H,45,46)/t28-/m0/s1^Y Key:XTSOSRWDZSKOSB-NDEPHWFRSA-N^Y
(verify)