AM-679 (cannabinoid)

AM-679 (cannabinoid)
Legal status
Legal status
Identifiers
  • (2-Iodophenyl)(1-pentyl-1H-indol-3-yl)methanone
CAS Number
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC20H20INO
Molar mass417.290 g·mol−1
3D model (JSmol)
  • Ic1ccccc1C(=O)c(c2ccccc23)cn3CCCCC
  • InChI=1S/C20H20INO/c1-2-3-8-13-22-14-17(15-9-5-7-12-19(15)22)20(23)16-10-4-6-11-18(16)21/h4-7,9-12,14H,2-3,8,13H2,1H3 Y
  • Key:GAJBHYUAJOTAEW-UHFFFAOYSA-N Y
 NY (what is this?)  (verify)

AM-679 (part of the AM cannabinoid series) is a drug that acts as a moderately potent agonist for the cannabinoid receptors, with a Ki of 13.5 nM at CB1 and 49.5 nM at CB2. AM-679 was one of the first 3-(2-iodobenzoyl)indole derivatives that was found to have significant cannabinoid receptor affinity, and while AM-679 itself has only modest affinity for these receptors, it was subsequently used as a base to develop several more specialised cannabinoid ligands that are now widely used in research, including the potent CB1 agonists AM-694 and AM-2233, and the selective CB2 agonist AM-1241. AM-679 was first identified as having been sold as a cannabinoid designer drug in Hungary in 2011, along with another novel compound 1-pentyl-3-(1-adamantoyl)indole.

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