APLP1

APLP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3PMR, 3Q7G, 3Q7L, 3QMK, 4RD9, 4RDA
Identifiers
Aliases	APLP1, APLP, amyloid beta precursor like protein 1
External IDs	OMIM: 104775; MGI: 88046; HomoloGene: 68447; GeneCards: APLP1; OMA:APLP1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	35,879,792 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	30,144,960 bp
RNA expression pattern
	Top expressed in
	C1 segment; ; inferior olivary nucleus; ; middle frontal gyrus; ; right frontal lobe; ; prefrontal cortex; ; caudate nucleus; ; nucleus accumbens; ; dorsal motor nucleus of vagus nerve; ; Amygdala; ; Hypothalamus;
	Top expressed in
	nucleus accumbens; ; nucleus of stria terminalis; ; piriform cortex; ; molar; ; subiculum; ; olfactory tubercle; ; central gray substance of midbrain; ; globus pallidus; ; primary visual cortex; ; superior colliculus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	alpha-2C adrenergic receptor binding; heparin binding; alpha-2B adrenergic receptor binding; metal ion binding; protein binding; alpha-2A adrenergic receptor binding; identical protein binding; transition metal ion binding;
Cellular component	cytoplasm; integral component of membrane; membrane; plasma membrane; basement membrane; perinuclear region of cytoplasm;
Biological process	endocytosis; nervous system development; cellular response to norepinephrine stimulus; cell adhesion; animal organ morphogenesis; apoptotic process; negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	333
	11803
	ENSG00000105290
	ENSMUSG00000006651
	P51693
	Q03157
	NM_005166; NM_001024807
	NM_007467
	NP_001019978; NP_005157
	NP_031493
	Wikidata
View/Edit Human	View/Edit Mouse

Amyloid precursor like protein 1, also known as APLP1, is a protein encoded by the APLP1 gene in humans. APLP1 along with APLP2 are important modulators of glucose and insulin homeostasis.