APPL1

APPL1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2EJ8, 2ELA, 2ELB, 2Q12, 2Q13, 2Z0N, 2Z0O, 5C5B
Identifiers
Aliases	APPL1, APPL, DIP13alpha, MODY14, adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
External IDs	OMIM: 604299; MGI: 1920243; HomoloGene: 32143; GeneCards: APPL1; OMA:APPL1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	57,278,105 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	26,693,189 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; biceps brachii; ; germinal epithelium; ; body of pancreas; ; vastus lateralis muscle; ; human penis; ; gastrocnemius muscle; ; Skeletal muscle tissue of biceps brachii; ; muscle of thigh; ; Skeletal muscle tissue of rectus abdominis;
	Top expressed in
	primary oocyte; ; aortic valve; ; ascending aorta; ; secondary oocyte; ; vestibular sensory epithelium; ; vestibular membrane of cochlear duct; ; substantia nigra; ; primitive streak; ; conjunctival fornix; ; iris;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein kinase B binding; protein binding; identical protein binding; phosphatidylserine binding; phosphatidylinositol binding; protein homodimerization activity; protein-containing complex binding; beta-tubulin binding;
Cellular component	cytoplasm; NuRD complex; cytosol; endosome; early endosome membrane; membrane; vesicle membrane; endosome membrane; extracellular exosome; nucleus; early endosome; ruffle; plasma membrane; cytoplasmic vesicle; early phagosome; macropinosome; intracellular vesicle; cell projection; phagocytic vesicle;
Biological process	regulation of glucose import; extrinsic apoptotic signaling pathway in absence of ligand; cell cycle; cell population proliferation; signal transduction; insulin receptor signaling pathway; regulation of protein localization to plasma membrane; transforming growth factor beta receptor signaling pathway; regulation of fibroblast migration; signaling; adiponectin-activated signaling pathway; regulation of toll-like receptor 4 signaling pathway; cellular response to hepatocyte growth factor stimulus; regulation of innate immune response; positive regulation of glucose import; positive regulation of melanin biosynthetic process; positive regulation of cytokine production involved in inflammatory response; positive regulation of macropinocytosis; negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis; protein import into nucleus;
	Sources:Amigo / QuickGO
Orthologs
	26060
	72993
	ENSG00000157500
	ENSMUSG00000040760
	Q9UKG1
	Q8K3H0
	NM_012096
	NM_145221
	NP_036228
	NP_660256
	Wikidata
View/Edit Human	View/Edit Mouse

Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 (APPL1), or DCC-interacting protein 13-alpha (DIP13alpha), is a protein that in humans is encoded by the APPL1 gene. APPL1 contains several key interactory domains: pleckstrin homology (PH) domain, phosphotyrosine-binding (PTB) domain and Bin–Amphiphysin–Rvs (BAR) domain.