AZIN1

AZIN1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4ZGZ
Identifiers
Aliases	AZIN1, AZI, AZIA1, OAZI, OAZIN, ODC1L, antizyme inhibitor 1, AZI1
External IDs	OMIM: 607909; MGI: 1859169; HomoloGene: 22933; GeneCards: AZIN1; OMA:AZIN1 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	102,893,864 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	38,519,510 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; ventricular zone; ; epithelium of nasopharynx; ; ganglionic eminence; ; epithelium of colon; ; cartilage tissue; ; placenta; ; bone marrow cells; ; jejunal mucosa; ; body of pancreas;
	Top expressed in
	fetal liver hematopoietic progenitor cell; ; atrioventricular valve; ; barrel cortex; ; spermatocyte; ; decidua; ; lacrimal gland; ; atrium; ; epithelium of lens; ; spermatid; ; salivary gland;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	ornithine decarboxylase activator activity; protein binding; catalytic activity; ornithine decarboxylase activity;
Cellular component	cytosol; nucleus; cytoplasm;
Biological process	polyamine biosynthetic process; positive regulation of polyamine transmembrane transport; regulation of cellular amino acid metabolic process; putrescine biosynthetic process from ornithine; positive regulation of catalytic activity; negative regulation of protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	51582
	54375
	ENSG00000155096
	ENSMUSG00000037458
	O14977
	O35484
NM_001301668; NM_015878; NM_148174; NM_001363010; NM_001363011;
	NM_001363012; NM_001363013; NM_001363014; NM_001363024; NM_001363083
	NM_001102458; NM_001301688; NM_018745
NP_001288597; NP_056962; NP_680479; NP_001349939; NP_001349940;
	NP_001349941; NP_001349942; NP_001349943; NP_001349953; NP_001350012
	NP_001095928; NP_001288617; NP_061215
	Wikidata
View/Edit Human	View/Edit Mouse

Antizyme inhibitor 1 is a protein that in humans is encoded by the AZIN1 gene.

Ornithine decarboxylase (ODC) catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. Ornithine decarboxylase antizymes play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. The protein encoded by this gene is highly similar to ODC. It binds to ODC antizyme and stabilizes ODC, thus inhibiting antizyme-mediated ODC degradation. Two alternatively spliced transcript variants have been found for this gene.