Adhesion molecule (immunoglobulin-like)
| Adhes-Ig_like | |||||||||
|---|---|---|---|---|---|---|---|---|---|
a reassessment of the madcam-1 structure and its role in integrin recognition. | |||||||||
| Identifiers | |||||||||
| Symbol | Adhes-Ig_like | ||||||||
| Pfam | PF09085 | ||||||||
| Pfam clan | CL0159 | ||||||||
| InterPro | IPR015169 | ||||||||
| SCOP2 | 1gsm / SCOPe / SUPFAM | ||||||||
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In molecular biology, the adhesin molecule (immunoglobulin-like) is a protein domain. This domain is found in mucosal vascular addressin cell adhesion molecule 1 proteins (MAdCAM-1). These are cell adhesion molecules expressed on the endothelium in mucosa that guide the specific homing of lymphocytes into mucosal tissues. MAdCAM-1 belongs to a subclass of the immunoglobulin superfamily (IgSF), the members of which are ligands for integrins. The crystal structure of this domain has been reported; it adopts an immunoglobulin-like beta-sandwich structure, with seven strands arranged in two beta-sheets in a Greek-key topology.