Advantame

Advantame
Names
	IUPAC name Methyl N-[3-(3-Hydroxy-4-methoxyphenyl)propyl]aspartylphenylalaninate
	Systematic IUPAC name (3S)-3-{[3-(3-Hydroxy-4-methoxyphenyl)propyl]amino}-4-{[(2S)-1-methoxy-1-oxo-3-phenylpropan-2-yl]amino}-4-oxobutanoic acid
	Other names N-[N-[3-(3-Hydroxy-4-methoxyphenyl)propyl]-α-L-aspartyl]-L-phenylalanine 1-methyl ester
Identifiers
CAS Number	714229-20-6 (monohydrate) ; 245650-17-3 (anhydrous) ;
3D model (JSmol)	Interactive image;
ChemSpider	8564873;
E number	E969 (glazing agents, ...)
PubChem CID	10389431;
UNII	3ZA6810AWX (monohydrate) ; M501L2WP44 (anhydrous) ;
CompTox Dashboard (EPA)	DTXSID60179302 ;
	InChI InChI=1S/C24H30N2O7/c1-32-21-11-10-17(14-20(21)27)9-6-12-25-18(15-22(28)29)23(30)26-19(24(31)33-2)13-16-7-4-3-5-8-16/h3-5,7-8,10-11,14,18-19,25,27H,6,9,12-13,15H2,1-2H3,(H,26,30)(H,28,29)/t18-,19-/m0/s1 Key: YTKBWWKAVMSYHE-OALUTQOASA-N; InChI=1/C24H30N2O7/c1-32-21-11-10-17(14-20(21)27)9-6-12-25-18(15-22(28)29)23(30)26-19(24(31)33-2)13-16-7-4-3-5-8-16/h3-5,7-8,10-11,14,18-19,25,27H,6,9,12-13,15H2,1-2H3,(H,26,30)(H,28,29)/t18-,19-/m0/s1 Key: YTKBWWKAVMSYHE-OALUTQOABU;
	SMILES COC1=C(C=C(C=C1)CCCN[C@@H](CC(=O)O)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)OC)O;
Properties
Chemical formula	C24H30N2O7
Molar mass	458.511 g·mol−1
Appearance	white to yellow powder
Melting point	101.5 °C (214.7 °F; 374.6 K)
Solubility in water	0.99 g/L at 25 °C
Hazards
Safety data sheet (SDS)	External MSDS
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Advantame is a non-caloric artificial sweetener and aspartame analog by Ajinomoto. By mass, it is about 20,000 times sweeter than sucrose and about 110 times sweeter than aspartame. It has no notable off-flavors when compared to sucrose and tastes sweet a bit longer than aspartame and is chemically more stable. It can be blended with many other natural and artificial sweeteners.

Advantame can be used as a table top sweetener and in certain bubblegums, flavored drinks, milk products, jams and confectionery among other things.

In 2013, it was approved for use in foods within EU with the E number E969. In 2014, FDA approved advantame as a non-nutritive sweetener and flavor enhancer within United States in foods generally, except meat and poultry.