BTNL2

BTNL2
Identifiers
Aliases	BTNL2, BTL-II, BTN7, HSBLMHC1, SS2, butyrophilin like 2
External IDs	OMIM: 606000; MGI: 1859549; HomoloGene: 10482; GeneCards: BTNL2; OMA:BTNL2 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	32,407,181 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	34,588,469 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; ventricular zone; ; gonad; ; ganglionic eminence; ; right ovary; ; lymph node; ; left ovary; ; superior frontal gyrus; ; smooth muscle tissue; ; endometrium;
	Top expressed in
	jejunum; ; duodenum; ; granulocyte; ; morula; ; ileum; ; epithelium of small intestine; ; colon; ; stomach; ; thymus; ; esophagus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	signaling receptor binding;
Cellular component	membrane; integral component of membrane; plasma membrane; external side of plasma membrane;
Biological process	regulation of immune response; T cell receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	56244
	547431
ENSG00000225845; ENSG00000229741; ENSG00000226127; ENSG00000224770; ENSG00000225412;
	ENSG00000224242; ENSG00000229597; ENSG00000204290; ENSG00000275798
	ENSMUSG00000024340
	Q9UIR0
	O70355
	NM_001304561; NM_019602
	NM_079835
	NP_001291490
	NP_524574
	Wikidata
View/Edit Human	View/Edit Mouse

Butyrophilin-like protein 2 is a protein that in humans is encoded by the BTNL2 gene.

Because it is associated with the immune system and the major histocompatibility complex, it has been implicated in many diseases (see further reading list below). A large scale study found it to be the protein under the most stringent selection in the human genome in 8 out of 12 geographic regions using the HKA test.