BUB1

BUB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2LAH, 4A1G, 4QPM, 4R8Q, 5DMZ
Identifiers
Aliases	BUB1, BUB1A, BUB1L, hBUB1 mitotic checkpoint serine/threonine kinase
External IDs	OMIM: 602452; MGI: 1100510; HomoloGene: 37910; GeneCards: BUB1; OMA:BUB1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	110,678,063 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	127,673,785 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; gonad; ; ganglionic eminence; ; right testis; ; left testis; ; secondary oocyte; ; testicle; ; bone marrow cells; ; mucosa of transverse colon; ; trabecular bone;
	Top expressed in
	tail of embryo; ; genital tubercle; ; abdominal wall; ; epiblast; ; primitive streak; ; otic placode; ; mandibular prominence; ; dermis; ; maxillary prominence; ; spermatid;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; kinase activity; protein serine/threonine kinase activity; protein binding; ATP binding;
Cellular component	membrane; nucleoplasm; chromosome; chromosome, centromeric region; nucleus; kinetochore; cytosol;
Biological process	phosphorylation; chromosome segregation; mitotic cell cycle checkpoint signaling; cell division; regulation of chromosome segregation; protein phosphorylation; cell cycle; regulation of sister chromatid cohesion; cell population proliferation; viral process; apoptotic process; sister chromatid cohesion; meiotic sister chromatid cohesion, centromeric; mitotic spindle assembly checkpoint signaling;
	Sources:Amigo / QuickGO
Orthologs
	699
	12235
	ENSG00000169679
	ENSMUSG00000027379
	O43683
	O08901
	NM_001278616; NM_001278617; NM_004336
	NM_001113179; NM_009772
	NP_001265545; NP_001265546; NP_004327
	NP_001106650; NP_033902
	Wikidata
View/Edit Human	View/Edit Mouse

Mitotic checkpoint serine/threonine-protein kinase BUB1 also known as BUB1 (budding uninhibited by benzimidazoles 1) is an enzyme that in humans is encoded by the BUB1 gene.

Bub1 is a serine/threonine protein kinase first identified in genetic screens of Saccharomyces cerevisiae (baker's yeast). The protein is bound to kinetochores and plays a key role in the establishment of the mitotic spindle checkpoint and chromosome congression. The mitotic checkpoint kinase is evolutionarily conserved in organisms as diverse as Saccharomyces cerevisiae and humans. Loss-of-function mutations or absence of Bub1 has been reported to result in aneuploidy, chromosomal instability (CIN) and premature senescence.