Bisoprolol

Bisoprolol
Clinical data
Trade names	Zebeta, Monocor, others
AHFS/Drugs.com	Monograph
MedlinePlus	a693024
Pregnancy; category	AU: C;
Routes of; administration	By mouth
ATC code	C07AB07 (WHO) ;
Legal status
Legal status	CA: ℞-only; US: ℞-only; In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	>90%
Protein binding	30%
Metabolism	50% liver, CYP2D6, CYP3A4
Elimination half-life	10–12 hours
Excretion	Kidney, fecal (<2%)
Identifiers
	IUPAC name (RS)-1-{4-[(2-Isopropoxyethoxy)methyl]phenoxy}-; 3-(isopropylamino)propan-2-ol;
CAS Number	66722-44-9 ;
PubChem CID	2405;
IUPHAR/BPS	7129;
DrugBank	DB00612 ;
ChemSpider	2312 ;
UNII	Y41JS2NL6U;
KEGG	D02342 ;
ChEBI	CHEBI:3127 ;
ChEMBL	ChEMBL645 ;
CompTox Dashboard (EPA)	DTXSID6022682 ;
ECHA InfoCard	100.108.941
Chemical and physical data
Formula	C18H31NO4
Molar mass	325.449 g·mol−1
3D model (JSmol)	Interactive image;
Chirality	Racemic mixture
	SMILES O(c1ccc(cc1)COCCOC(C)C)CC(O)CNC(C)C;
	InChI InChI=1S/C18H31NO4/c1-14(2)19-11-17(20)13-23-18-7-5-16(6-8-18)12-21-9-10-22-15(3)4/h5-8,14-15,17,19-20H,9-13H2,1-4H3 ; Key:VHYCDWMUTMEGQY-UHFFFAOYSA-N ;
	(verify)

Bisoprolol, sold under the brand names Bisotab, Concor, Corbis and Zebeta among others, is a beta blocker which is selective for the beta-1 receptor and used for cardiovascular diseases, including tachyarrhythmias, high blood pressure, angina, and heart failure. It is taken by mouth.

Common side effects include headache, feeling tired, diarrhea, and swelling in the legs. More severe side effects include worsening asthma, blocking the ability to recognize low blood sugar, and worsening heart failure. There are concerns that use during pregnancy may be harmful to the baby.

Bisoprolol was patented in 1976 and approved for medical use in 1986. It was approved for medical use in the United States in 1992.

Bisoprolol is on the World Health Organization's List of Essential Medicines and is available as a generic medication. In 2022, it was the 249th most commonly prescribed medication in the United States, with more than 1 million prescriptions.