C-DMT

C-DMT
Clinical data
Other names	N,N-Dimethyl-3-indenylethylamine; 3-(2-Dimethylaminoethyl)indene; N,N-Dimethyl-2-(3H-inden-1-yl)ethylamine
Drug class	Serotonin receptor agonist
Identifiers
	IUPAC name 2-(3H-inden-1-yl)-N,N-dimethylethanamine;
PubChem CID	547452;
ChemSpider	476501;
ChEMBL	ChEMBL161241;
Chemical and physical data
Formula	C13H17N
Molar mass	187.286 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CN(C)CCC1=CCC2=CC=CC=C21;
	InChI InChI=1S/C13H17N/c1-14(2)10-9-12-8-7-11-5-3-4-6-13(11)12/h3-6,8H,7,9-10H2,1-2H3; Key:FOBWFOXXVASKOU-UHFFFAOYSA-N;

C-DMT, also known as N,N-dimethyl-2-(3H-inden-1-yl)ethylamine, is a serotonin receptor agonist and a 3-indenyl ethyl amine derivative. It is an analogue and bioisostere of the tryptamine psychedelic N,N-dimethyltryptamine (DMT) in which the indole ring has been replaced with an indene ring. Put another way, the nitrogen atom in the indole ring of DMT has been replaced with a carbon atom to make an indene ring.

The drug shows similar affinity for and potency in activating the serotonin receptors in the rat fundus strip compared to DMT. These findings suggest that the indole-ring nitrogen atom of tryptamines is not essential for serotonergic activity. On the other hand however, C-DMT showed dramatically lower affinities for the serotonin 5-HT_1E and 5-HT_1F receptors compared to DMT (8- and 65-fold, respectively).

The effects of C-DMT in animals and humans, and whether it produces hallucinogenic effects, do not appear to be known.