CAMK4

CAMK4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2W4O
Identifiers
Aliases	CAMK4, CaMK IV, CaMK-GR, IV, caMK, calcium/calmodulin-dependent protein kinase IV, calcium/calmodulin dependent protein kinase IV, CaMKIV
External IDs	OMIM: 114080; MGI: 88258; HomoloGene: 100780; GeneCards: CAMK4; OMA:CAMK4 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	111,494,886 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	33,324,281 bp
RNA expression pattern
	Top expressed in
	cerebellar vermis; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; middle temporal gyrus; ; left testis; ; right testis; ; paraflocculus of cerebellum; ; ganglionic eminence; ; nucleus accumbens; ; superior frontal gyrus;
	Top expressed in
	cerebellar cortex; ; superior frontal gyrus; ; thymus; ; primary visual cortex; ; lobe of cerebellum; ; seminiferous tubule; ; dentate gyrus of hippocampal formation granule cell; ; cerebellar vermis; ; spermatid; ; olfactory tubercle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; calcium-dependent protein serine/threonine kinase activity; calmodulin binding; kinase activity; protein serine/threonine kinase activity; calmodulin-dependent protein kinase activity; ATP binding;
Cellular component	cytoplasm; cytosol; nucleoplasm; extracellular exosome; nucleus; fibrillar center; postsynapse; glutamatergic synapse;
Biological process	intracellular signal transduction; adaptive immune response; myeloid dendritic cell cytokine production; phosphorylation; immune system process; myeloid dendritic cell differentiation; positive regulation of transcription, DNA-templated; regulation of T cell differentiation in thymus; protein phosphorylation; regulation of osteoclast differentiation; long-term memory; peptidyl-serine phosphorylation; protein autophosphorylation; inflammatory response; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	814
	12326
	ENSG00000152495
	ENSMUSG00000038128
	Q16566
	P08414; Q8BGR3
	NM_001744; NM_001323374; NM_001323375; NM_001323376; NM_001323377
	NM_009793
	NP_001310303; NP_001310304; NP_001310305; NP_001310306; NP_001735
	NP_033923
	Wikidata
View/Edit Human	View/Edit Mouse

Calcium/calmodulin-dependent protein kinase type IV is an enzyme that in humans is encoded by the CAMK4 gene.

The product of this gene belongs to the serine/threonine protein kinase cluster, and to the Ca²⁺/calmodulin-dependent protein kinase (CAMK) group. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons, and male germ cells.