Caspase 12

CASP12
Identifiers
Aliases	CASP12, CASP-12, CASP12P1, caspase 12 (gene/pseudogene), caspase 12, Caspase-12, Caspase_12, IPR035713
External IDs	OMIM: 608633; MGI: 1312922; GeneCards: CASP12; OMA:CASP12 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	104,898,670 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	5,373,032 bp
RNA expression pattern
	Top expressed in
	testicle; ; right lung; ; left ovary; ; gastric mucosa; ; ascending aorta; ; Descending thoracic aorta; ; popliteal artery; ; tibial arteries; ; left coronary artery; ; right ovary;
	Top expressed in
	temporal muscle; ; tunica media of zone of aorta; ; sternocleidomastoid muscle; ; lumbar spinal ganglion; ; triceps brachii muscle; ; intercostal muscle; ; uterus; ; carotid body; ; ascending aorta; ; semi-lunar valve;
	More reference expression data
	n/a
Gene ontology
Molecular function	cysteine-type endopeptidase activity involved in apoptotic process; cysteine-type peptidase activity; cysteine-type endopeptidase activity; cysteine-type endopeptidase activity involved in apoptotic signaling pathway;
Cellular component	NLRP3 inflammasome complex; AIM2 inflammasome complex; IPAF inflammasome complex; endoplasmic reticulum; cytoplasm;
Biological process	regulation of apoptotic process; regulation of inflammatory response; proteolysis; execution phase of apoptosis; apoptotic process; activation of cysteine-type endopeptidase activity involved in apoptotic process; apoptotic signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	100506742
	12364
	ENSG00000204403
	ENSMUSG00000025887
	Q6UXS9
	O08736
	NM_001191016
	NM_009808
	NP_001177945
	NP_033938
	Wikidata
View/Edit Human	View/Edit Mouse

Caspase 12 is a protein that in humans is encoded by the CASP12 gene. The protein belongs to a family of enzymes called caspases which cleave their substrates at C-terminal aspartic acid residues. It is closely related to caspase 1 and other members of the caspase family, known as inflammatory caspases, which process and activate inflammatory cytokines such as interleukin 1 and interleukin 18.