CBLL1

CBLL1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2MQ1, 3VK6
Identifiers
Aliases	CBLL1, HAKAI, RNF188, Cbl proto-oncogene like 1
External IDs	OMIM: 606872; MGI: 2144842; HomoloGene: 11734; GeneCards: CBLL1; OMA:CBLL1 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	107,761,667 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	31,549,615 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; epithelium of colon; ; muscle of thigh; ; endothelial cell; ; bone marrow; ; germinal epithelium; ; bone marrow cells; ; oocyte; ; gastrocnemius muscle; ; gonad;
	Top expressed in
	Rostral migratory stream; ; genital tubercle; ; tail of embryo; ; retinal pigment epithelium; ; trigeminal ganglion; ; zygote; ; secondary oocyte; ; lacrimal gland; ; ciliary body; ; lateral septal nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; metal ion binding; ubiquitin protein ligase activity; identical protein binding; ubiquitin-protein transferase activity; transferase activity; zinc ion binding;
Cellular component	ubiquitin ligase complex; nucleus; nucleoplasm; cytosol; nuclear speck; cytoplasm; RNA N6-methyladenosine methyltransferase complex;
Biological process	positive regulation of cell migration; negative regulation of cell adhesion; positive regulation of endocytosis; regulation of cell adhesion; protein ubiquitination; entry of bacterium into host cell; cell-cell adhesion; mRNA methylation; multicellular organism development;
	Sources:Amigo / QuickGO
Orthologs
	79872
	104836
	ENSG00000105879
	ENSMUSG00000020659
	Q75N03
	Q9JIY2
	NM_001284291; NM_024814
	NM_001253847; NM_001253848; NM_134048
	NP_001271220; NP_079090
	NP_001240776; NP_001240777; NP_598809
	Wikidata
View/Edit Human	View/Edit Mouse

The E3 ubiquitin-protein ligase Hakai (HAKAI) also known as Casitas B-lineage lymphoma-transforming sequence-like protein 1 (CBLL1) is an enzyme that in humans is encoded by the CBLL1 gene. This gene encodes an E3 ubiquitin ligase for the E-cadherin complex and mediates its ubiquitination, endocytosis, and degradation in the lysosomes. The encoded protein contains a RING-finger domain and is also thought to have a role in control of cell proliferation.