CBR3

CBR3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2HRB
Identifiers
Aliases	CBR3, HEL-S-25, SDR21C2, hcarbonyl reductase 3
External IDs	OMIM: 603608; MGI: 1309992; HomoloGene: 20332; GeneCards: CBR3; OMA:CBR3 - orthologs
Gene location (Human)
Chr.	Chromosome 21 (human)
End	36,146,562 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	93,487,878 bp
RNA expression pattern
	Top expressed in
	gingival epithelium; ; tendon of biceps brachii; ; olfactory zone of nasal mucosa; ; parotid gland; ; cartilage tissue; ; minor salivary glands; ; vulva; ; oral cavity; ; mucosa of pharynx; ; Achilles tendon;
	Top expressed in
	epithelium of stomach; ; pyloric antrum; ; mucous cell of stomach; ; cervix; ; esophagus; ; stroma of bone marrow; ; skin of external ear; ; ankle joint; ; lip; ; dorsal striatum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity; NADPH binding; carbonyl reductase (NADPH) activity; 3-keto sterol reductase activity; protein binding;
Cellular component	nucleoplasm; extracellular space; cytoplasm; cytosol;
Biological process	phylloquinone catabolic process; cognition; xenobiotic metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	874
	109857
	ENSG00000159231
	ENSMUSG00000022947
	O75828
	Q8K354
	NM_001236
	NM_173047
	NP_001227
	NP_766635
	Wikidata
View/Edit Human	View/Edit Mouse

Carbonyl reductase [NADPH] 3 is an enzyme that in humans is encoded by the CBR3 gene.

Carbonyl reductase 3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. The enzyme is classified as a monomeric NADPH-dependent oxidoreductase. CBR3 contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl reductase gene - CBR1.