CCL22

CCL22
Identifiers
Aliases	CCL22, A-152E5.1, ABCD-1, DC/B-CK, MDC, SCYA22, STCP-1, C-C motif chemokine ligand 22
External IDs	OMIM: 602957; MGI: 1306779; HomoloGene: 7529; GeneCards: CCL22; OMA:CCL22 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	57,366,189 bp
RNA expression pattern
	Top expressed in
	appendix; ; mucosa of urinary bladder; ; lymph node; ; rectum; ; pharynx; ; palpebral conjunctiva; ; vulva; ; tonsil; ; epithelium of colon; ; skin of abdomen;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cytokine activity; CCR chemokine receptor binding; chemokine activity;
Cellular component	extracellular region; extracellular space;
Biological process	G protein-coupled receptor signaling pathway; monocyte chemotaxis; chemokine-mediated signaling pathway; cell-cell signaling; cellular response to tumor necrosis factor; response to virus; neutrophil chemotaxis; chemotaxis; positive regulation of GTPase activity; immune response; cellular response to interleukin-1; positive regulation of ERK1 and ERK2 cascade; cellular response to interferon-gamma; cell chemotaxis; lymphocyte chemotaxis; signal transduction; inflammatory response; antimicrobial humoral immune response mediated by antimicrobial peptide; regulation of signaling receptor activity; cytokine-mediated signaling pathway; eosinophil chemotaxis;
	Sources:Amigo / QuickGO
Orthologs
	6367
	20299
	ENSG00000102962
	n/a
	O00626
	O88430
	NM_002990
	NM_009137
	NP_002981
	NP_033163
	Wikidata
View/Edit Human	View/Edit Mouse

C-C motif chemokine 22 is a protein that in humans is encoded by the CCL22 gene.

The protein encoded by this gene is secreted by dendritic cells and macrophages, and elicits its effects on its target cells by interacting with cell surface chemokine receptors such as CCR4. The gene for CCL22 is located in human chromosome 16 in a cluster with other chemokines called CX3CL1 and CCL17.