CCNB1IP1

CCNB1IP1
Identifiers
Aliases	CCNB1IP1, C14orf18, HEI10, cyclin B1 interacting protein 1
External IDs	OMIM: 608249; MGI: 2685134; HomoloGene: 18819; GeneCards: CCNB1IP1; OMA:CCNB1IP1 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	20,333,312 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	51,045,189 bp
RNA expression pattern
	Top expressed in
	left ovary; ; ganglionic eminence; ; right ovary; ; gastric mucosa; ; cartilage tissue; ; ventricular zone; ; body of uterus; ; apex of heart; ; right auricle of heart; ; left ventricle;
	Top expressed in
	epiblast; ; fetal liver hematopoietic progenitor cell; ; embryo; ; morula; ; spermatocyte; ; primitive streak; ; embryo; ; blastocyst; ; otic placode; ; primary oocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; metal ion binding; ubiquitin protein ligase activity; transferase activity;
Cellular component	condensed nuclear chromosome; synaptonemal complex; nucleus; chromosome;
Biological process	reciprocal meiotic recombination; chiasma assembly; meiosis; blastocyst formation; protein ubiquitination; spermatid development;
	Sources:Amigo / QuickGO
Orthologs
	57820
	239083
	ENSG00000100814
	ENSMUSG00000071470
	Q9NPC3
	D3Z3K2
	NM_182852; NM_021178; NM_182849; NM_182851
	NM_001111119
	NP_067001; NP_878269; NP_878272
	NP_001104589
	Wikidata
View/Edit Human	View/Edit Mouse

E3 ubiquitin-protein ligase CCNB1IP1 is an enzyme that in humans is encoded by the CCNB1IP1 gene.

HEI10 is a member of the E3 ubiquitin ligase family and functions in progression of the cell cycle through G(2)/M.[supplied by OMIM] It is considered a housekeeping gene.

During meiosis, crossing over between homologous chromosomes (homologs) facilitates accurate chromosome segregation. In mammals, the ring-domain protein CCNB1IP1, also known as HEI10, promotes crossing over between each pair of homologs during meiosis. Studies in the mouse showed that this pro-crossover ring-domain protein facilitates the homologous recombination and DNA repair processes that produce crossovers.