SLAMF7

SLAMF7
Identifiers
Aliases	SLAMF7, 19A, CD319, CRACC, CS1, SLAM family member 7
External IDs	OMIM: 606625; MGI: 1922595; HomoloGene: 49660; GeneCards: SLAMF7; OMA:SLAMF7 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	160,754,821 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	171,480,603 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; lymph node; ; epithelium of colon; ; rectum; ; mucosa of sigmoid colon; ; bone marrow cells; ; spleen; ; monocyte; ; palpebral conjunctiva; ; blood;
	Top expressed in
	interventricular septum; ; spermatocyte; ; spermatid; ; seminiferous tubule; ; spleen; ; mesenteric lymph nodes; ; granulocyte; ; zygote; ; right kidney; ; thymus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	identical protein binding;
Cellular component	integral component of membrane; plasma membrane; membrane;
Biological process	cell adhesion; natural killer cell activation; innate immune response; adaptive immune response; natural killer cell mediated cytotoxicity; regulation of immune response; immune system process;
	Sources:Amigo / QuickGO
Orthologs
	57823
	75345
	ENSG00000026751
	ENSMUSG00000038179
	Q9NQ25
	Q8BHK6
NM_001282588; NM_001282589; NM_001282590; NM_001282591; NM_001282592;
	NM_001282593; NM_001282594; NM_001282595; NM_001282596; NM_021181
	NM_144539; NM_001347184
NP_001269517; NP_001269518; NP_001269519; NP_001269520; NP_001269521;
	NP_001269522; NP_001269523; NP_001269524; NP_001269525; NP_067004
	NP_001334113; NP_653122
	Wikidata
View/Edit Human	View/Edit Mouse

SLAM family member 7 is a protein that in humans is encoded by the SLAMF7 gene.

The surface antigen CD319 (SLAMF7) is a robust marker of normal plasma cells and malignant plasma cells in multiple myeloma. In contrast to CD138 (the traditional plasma cell marker), CD319/SLAMF7 is much more stable and allows robust isolation of malignant plasma cells from delayed or even cryopreserved samples.

Elotuzumab is an antibody that targets this protein.