CDKN1B

CDKN1B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2AST, 1H27, 1JSU
Identifiers
Aliases	CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1, cyclin-dependent kinase inhibitor 1B, cyclin dependent kinase inhibitor 1B
External IDs	OMIM: 600778; MGI: 104565; HomoloGene: 2999; GeneCards: CDKN1B; OMA:CDKN1B - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	12,722,369 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	134,902,476 bp
RNA expression pattern
	Top expressed in
	retinal pigment epithelium; ; ventricular zone; ; ganglionic eminence; ; Pons; ; lateral nuclear group of thalamus; ; trabecular bone; ; parietal pleura; ; superficial temporal artery; ; germinal epithelium; ; cerebellar vermis;
	Top expressed in
	cerebellar vermis; ; lobe of cerebellum; ; blood; ; pineal gland; ; cumulus cell; ; ventricular zone; ; granulocyte; ; habenula; ; ganglionic eminence; ; seminal vesicula;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; protein phosphatase binding; cyclin-dependent protein serine/threonine kinase activity; protein kinase inhibitor activity; protein kinase binding; cyclin binding; cyclin-dependent protein serine/threonine kinase inhibitor activity; Hsp70 protein binding; protein-containing complex binding; chaperone binding;
Cellular component	cytoplasm; cytosol; endosome; nucleoplasm; Cul4A-RING E3 ubiquitin ligase complex; nucleus; intracellular membrane-bounded organelle; protein-containing complex;
Biological process	Notch signaling pathway; regulation of cyclin-dependent protein serine/threonine kinase activity; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; response to estradiol; positive regulation of cell death; response to hypoxia; response to amino acid; response to cadmium ion; positive regulation of protein catabolic process; response to organic cyclic compound; cellular response to lithium ion; cellular response to organic cyclic compound; response to peptide hormone; cell death; negative regulation of apoptotic process; hearing; response to glucose; potassium ion transport; regulation of cell population proliferation; negative regulation of cell growth; negative regulation of epithelial cell proliferation involved in prostate gland development; positive regulation of cell population proliferation; positive regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of epithelial cell proliferation; positive regulation of microtubule polymerization; inner ear development; cellular response to antibiotic; cell cycle; negative regulation of phosphorylation; negative regulation of transcription, DNA-templated; autophagic cell death; negative regulation of cell population proliferation; negative regulation of mitotic cell cycle; negative regulation of kinase activity; positive regulation of cell cycle; negative regulation of vascular associated smooth muscle cell proliferation; placenta development; regulation of exit from mitosis; regulation of lens fiber cell differentiation; negative regulation of cyclin-dependent protein kinase activity; negative regulation of cell cycle; negative regulation of cyclin-dependent protein serine/threonine kinase activity; G1/S transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	1027
	12576
	ENSG00000111276
	ENSMUSG00000003031
	P46527
	P46414
	NM_004064
	NM_009875
	NP_004055
	NP_034005
	Wikidata
View/Edit Human	View/Edit Mouse

Cyclin-dependent kinase inhibitor 1B (p27^Kip1) is an enzyme inhibitor that in humans is encoded by the CDKN1B gene. It encodes a protein which belongs to the Cip/Kip family of cyclin dependent kinase (Cdk) inhibitor proteins. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. It is often referred to as a cell cycle inhibitor protein because its major function is to stop or slow down the cell division cycle.