Homeobox protein CDX-2

CDX2
Identifiers
Aliases	CDX2, CDX-3, CDX2/AS, CDX3, caudal type homeobox 2, Cdx2
External IDs	OMIM: 600297; MGI: 88361; HomoloGene: 968; GeneCards: CDX2; OMA:CDX2 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	27,969,315 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	147,244,080 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; rectum; ; duodenum; ; epithelium of colon; ; mucosa of ileum; ; mucosa of sigmoid colon; ; appendix; ; jejunal mucosa; ; body of pancreas; ; islet of Langerhans;
	Top expressed in
	Paneth cell; ; tail of embryo; ; crypt of lieberkuhn of small intestine; ; primitive streak; ; migratory enteric neural crest cell; ; ileum; ; jejunum; ; duodenum; ; Epithelium of large intestine; ; left colon;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; sequence-specific DNA binding; transcription corepressor activity; DNA-binding transcription factor activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; double-stranded DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; methyl-CpG binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding;
Cellular component	transcription repressor complex; nucleoplasm; condensed nuclear chromosome; nucleus; protein-containing complex;
Biological process	pattern specification process; cell differentiation; regulation of transcription, DNA-templated; regulation of somitogenesis; somatic stem cell population maintenance; endosome to lysosome transport; placenta development; regulation of transcription by RNA polymerase II; labyrinthine layer development; negative regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; transcription, DNA-templated; positive regulation of transcription, DNA-templated; multicellular organism development; blood vessel development; trophectodermal cell differentiation; establishment or maintenance of epithelial cell apical/basal polarity; positive regulation of cell differentiation; intestinal epithelial cell differentiation; positive regulation of cell population proliferation; animal organ morphogenesis; anterior/posterior axis specification; blastocyst development; anterior/posterior pattern specification;
	Sources:Amigo / QuickGO
Orthologs
	1045
	12591
	ENSG00000165556
	ENSMUSG00000029646
	Q99626
	P43241
	NM_001265; NM_001354700
	NM_007673
	NP_001256; NP_001341629
	NP_031699
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein CDX-2 is a protein that in humans is encoded by the CDX2 gene. The CDX-2 protein is a homeobox transcription factor expressed in the nuclei of intestinal epithelial cells, playing an essential role in the development and function of the digestive system. CDX2 is part of the ParaHox gene cluster, a group of three highly conserved developmental genes present in most vertebrate species. Together with CDX1 and CDX4, CDX2 is one of three caudal-related genes in the human genome.