CEP250

CEP250
Identifiers
Aliases	CEP250, C-NAP1, CEP2, CNAP1, centrosomal protein 250, CRDHL2
External IDs	OMIM: 609689; MGI: 108084; HomoloGene: 38286; GeneCards: CEP250; OMA:CEP250 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	35,519,280 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	155,840,820 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; ventricular zone; ; granulocyte; ; ganglionic eminence; ; stromal cell of endometrium; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; Achilles tendon; ; lymph node; ; epithelium of colon;
	Top expressed in
	neural layer of retina; ; granulocyte; ; tail of embryo; ; ventricular zone; ; genital tubercle; ; yolk sac; ; thymus; ; Jacobson's organ; ; zygote; ; secondary oocyte;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein domain specific binding; protein C-terminus binding; protein binding; protein kinase binding;
Cellular component	cytoplasm; cytosol; centrosome; cell projection; cilium; microtubule organizing center; perinuclear region of cytoplasm; centriole; extracellular exosome; cytoskeleton; protein-containing complex;
Biological process	protein localization to organelle; protein localization; regulation of centriole-centriole cohesion; centriole-centriole cohesion; G2/M transition of mitotic cell cycle; cell cycle; mitotic cell cycle; ciliary basal body-plasma membrane docking; positive regulation of protein localization to centrosome; non-motile cilium assembly; regulation of G2/M transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	11190
	16328
	ENSG00000126001
	ENSMUSG00000038241
	Q9BV73
	Q60952
	NM_001035518; NM_007186; NM_001318219
	NM_001129999; NM_001130000; NM_008383; NM_177217
	NP_001305148; NP_009117
	NP_001123471; NP_001123472; NP_032409; NP_796191
	Wikidata
View/Edit Human	View/Edit Mouse

Centrosome-associated protein CEP250 is a protein that in humans is encoded by the CEP250 gene. This gene encodes a core centrosomal protein required for centriole-centriole cohesion during interphase of the cell cycle. The encoded protein dissociates from the centrosomes when parental centrioles separate at the beginning of mitosis. The protein associates with and is phosphorylated by NIMA-related kinase 2, which is also associated with the centrosome. Furthermore, CEP135 is also required for the centriolar localization of CEP250.