CKAP5

CKAP5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4QMI, 4QMJ
Identifiers
Aliases	CKAP5, CHTOG, MSPS, TOG, TOGp, ch-TOG, cytoskeleton associated protein 5
External IDs	OMIM: 611142; MGI: 1923036; HomoloGene: 8844; GeneCards: CKAP5; OMA:CKAP5 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	46,846,308 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	91,451,009 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; oocyte; ; right testis; ; stromal cell of endometrium; ; Achilles tendon; ; left testis; ; secondary oocyte; ; prefrontal cortex; ; cerebellar hemisphere;
	Top expressed in
	tail of embryo; ; genital tubercle; ; ventricular zone; ; gastrula; ; ganglionic eminence; ; cerebellar cortex; ; maxillary prominence; ; secondary oocyte; ; mandibular prominence; ; zygote;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; cadherin binding; microtubule plus-end binding;
Cellular component	cytoplasm; cytosol; centrosome; spindle pole; membrane; microtubule cytoskeleton; gamma-tubulin complex; microtubule organizing center; microtubule plus-end; cytoskeleton; chromosome, centromeric region; kinetochore; chromosome; spindle; nucleolus; plasma membrane; protein-containing complex;
Biological process	RNA transport; establishment or maintenance of microtubule cytoskeleton polarity; cell division; spindle organization; G2/M transition of mitotic cell cycle; cell cycle; sister chromatid cohesion; centrosome cycle; microtubule polymerization; centrosome duplication; ciliary basal body-plasma membrane docking; regulation of G2/M transition of mitotic cell cycle; microtubule depolymerization;
	Sources:Amigo / QuickGO
Orthologs
	9793
	75786
	ENSG00000175216
	ENSMUSG00000040549
	Q14008
	A2AGT5
	NM_014756; NM_001008938
	NM_001165989; NM_029437
	NP_001008938; NP_055571
	NP_001159461; NP_083713
	Wikidata
View/Edit Human	View/Edit Mouse

Cytoskeleton-associated protein 5 is a microtubule-associated protein that in humans is encoded by the CKAP5 gene. It is the homolog of the Xenopus protein XMAP215 and is also known as ch-Tog.

It has at least two distinct roles in spindle formation: it protects kinetochore microtubules from depolymerization by MCAK (KIF2C), and ch-Tog plays an essential role in centrosomal microtubule assembly, a function independent of MCAK activity.