CLEC5A

CLEC5A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2YHF
Identifiers
Aliases	CLEC5A, CLECSF5, MDL-1, MDL1, C-type lectin domain family 5 member A, C-type lectin domain containing 5A
External IDs	OMIM: 604987; MGI: 1345151; HomoloGene: 8302; GeneCards: CLEC5A; OMA:CLEC5A - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	141,947,007 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	40,562,755 bp
RNA expression pattern
	Top expressed in
	bone marrow; ; bone marrow cells; ; trabecular bone; ; monocyte; ; testicle; ; right coronary artery; ; granulocyte; ; upper lobe of left lung; ; tibial nerve; ; Descending thoracic aorta;
	Top expressed in
	granulocyte; ; embryo; ; bone marrow; ; tibiofemoral joint; ; stroma of bone marrow; ; lumbar subsegment of spinal cord; ; calvaria; ; right kidney; ; dentate gyrus of hippocampal formation granule cell; ; esophagus;
	More reference expression data
	n/a
Gene ontology
Molecular function	carbohydrate binding; virus receptor activity; protein binding;
Cellular component	integral component of membrane; integral component of plasma membrane; membrane; cell surface; specific granule membrane; tertiary granule membrane; cytosol; plasma membrane;
Biological process	cellular defense response; myeloid cell differentiation; negative regulation of myeloid cell apoptotic process; viral process; signal transduction; immune system process; viral entry into host cell; negative regulation of apoptotic process; osteoblast development; innate immune response; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	23601
	23845
	ENSG00000258227
	ENSMUSG00000029915
	Q9NY25
	Q9R007
	NM_001301167; NM_013252
	NM_001038604; NM_021364
	NP_001288096; NP_037384
	NP_001033693; NP_067339
	Wikidata
View/Edit Human	View/Edit Mouse

C-type lectin domain family 5 member A (CLEC5A), also known as C-type lectin superfamily member 5 (CLECSF5) and myeloid DAP12-associating lectin 1 (MDL-1) is a C-type lectin that in humans is encoded by the CLEC5A gene.

Structurally MDL-1 is a type II transmembrane protein with a short cytoplasmic tail and without signaling motifs, therefore it requires association with the adaptor protein DAP12 to generate signals via Syk pathway.

MDL-1 is highly expressed on myeloid lineages like neutrophil, monocyte, macrophage and also osteoclast, microglia and dendritic cells.

Activation of MDL-1 induces production of many cytokines (TNF-α, IL-1, IL-6, IL-8 and IL-17A) and chemokines (MIP-1α, RANTES, IP-10, MDC). MDL-1 also amplifies innate immune response.