CPVL

CPVL
Identifiers
AliasesCPVL, HVLP, carboxypeptidase, vitellogenic like, carboxypeptidase vitellogenic like
External IDsOMIM: 609780; MGI: 1918537; HomoloGene: 80235; GeneCards: CPVL; OMA:CPVL - orthologs
Orthologs
SpeciesHumanMouse
Entrez

54504

71287

Ensembl

ENSG00000106066

ENSMUSG00000052955

UniProt

Q9H3G5

Q9D3S9

RefSeq (mRNA)

NM_019029
NM_031311
NM_001348052
NM_001348054

NM_001289713
NM_001289714
NM_027749

RefSeq (protein)

NP_001276642
NP_001276643
NP_082025

Location (UCSC)Chr 7: 29 – 29.2 MbChr 6: 53.85 – 53.96 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Probable serine carboxypeptidase CPVL is an enzyme that in humans is encoded by the CPVL gene. The "CPVL" gene is expressed mainly in monocytes and macrophages, and it is located in the endoplasmatic reticulum and in the endosomal/lysosomal compartment. The distribution of CPVL suggests that the enzyme may be involved in antigen processing and the secretory pathway. Besides those macrophages-rich tissues, the heart and kidney also express high levels of CPVL mRNA.The enzyme is similar to the carboxypeptidases CATHA and SCPEP1, but no direct confirmation of the enzymatic activity was obtained so far. The exact function of this protein, however, has not been determined.