Rootletin

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Rootletin
Rootletin
Identifiers
Symbol	Rootletin
Pfam	PF15035
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

CROCC
Identifiers
Aliases	CROCC, ROLT, ciliary rootlet coiled-coil, rootletin, TAX1BP2
External IDs	OMIM: 615776; MGI: 3529431; HomoloGene: 16811; GeneCards: CROCC; OMA:CROCC - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	16,972,964 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	140,787,861 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; sural nerve; ; right hemisphere of cerebellum; ; olfactory zone of nasal mucosa; ; granulocyte; ; apex of heart; ; right ovary; ; canal of the cervix; ; left uterine tube; ; body of uterus;
	Top expressed in
	neural layer of retina; ; superior frontal gyrus; ; lens; ; olfactory tubercle; ; retinal pigment epithelium; ; ventricular zone; ; otic vesicle; ; primary visual cortex; ; subiculum; ; epithelium of lens;
	More reference expression data
	n/a
Gene ontology
Molecular function	structural molecule activity; protein binding; kinesin binding; actin binding;
Cellular component	centrosome; photoreceptor inner segment; plasma membrane; ciliary rootlet; actin cytoskeleton; centriole; extracellular exosome; cytoskeleton; cytoplasm; cytosol; microtubule organizing center; cilium; cell projection;
Biological process	protein localization to organelle; protein localization; epithelial structure maintenance; ciliary basal body organization; establishment of organelle localization; centriole-centriole cohesion; cell projection organization; cell cycle; photoreceptor cell maintenance; positive regulation of cilium assembly; positive regulation of protein localization to cilium; centrosome cycle;
	Sources:Amigo / QuickGO
Orthologs
	9696
	230872
	ENSG00000058453
	ENSMUSG00000040860
	Q5TZA2
	Q8CJ40
	NM_014675
	NM_001145958; NM_172122
	NP_055490
	NP_001139430; NP_742120
	Wikidata
View/Edit Human	View/Edit Mouse

Rootletin, also known as ciliary rootlet coiled-coil protein (CROCC) is a protein in humans that is encoded by the CROCC gene. Rootletin is a component of the ciliary rootlet and, together with CEP68 and CEP250, is required for centrosome cohesion.

Rootletin is an important protein in the ciliary rootlet, particularly for the structure and is considered important protein in mitosis as a centrosome linker.