CSTF3

CSTF3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2OND, 2OOE
Identifiers
Aliases	CSTF3, CSTF-77, cleavage stimulation factor subunit 3
External IDs	OMIM: 600367; MGI: 1351825; HomoloGene: 1014; GeneCards: CSTF3; OMA:CSTF3 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	33,162,371 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	104,495,774 bp
RNA expression pattern
	Top expressed in
	anterior pituitary; ; tendon of biceps brachii; ; ganglionic eminence; ; corpus epididymis; ; ventricular zone; ; right hemisphere of cerebellum; ; right uterine tube; ; buccal mucosa cell; ; right testis; ; sperm;
	Top expressed in
	primitive streak; ; neural layer of retina; ; superior cervical ganglion; ; otic placode; ; abdominal wall; ; atrioventricular junction; ; ganglionic eminence; ; epiblast; ; endocardial cushion; ; ventricular zone;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; mRNA binding; RNA binding;
Cellular component	nucleus; nucleoplasm;
Biological process	mRNA splicing, via spliceosome; termination of RNA polymerase II transcription; mRNA polyadenylation; mRNA cleavage; RNA processing; mRNA processing; mRNA 3'-end processing; RNA 3'-end processing;
	Sources:Amigo / QuickGO
Orthologs
	1479
	228410
	ENSG00000176102
	ENSMUSG00000027176
	Q12996
	Q99LI7
	NM_001033505; NM_001033506; NM_001326
	NM_001037326; NM_145529; NM_177253
	NP_001028677; NP_001028678; NP_001317
	NP_001032403; NP_663504; NP_796227
	Wikidata
View/Edit Human	View/Edit Mouse

Cleavage stimulation factor 77 kDa subunit is a protein that in humans is encoded by the CSTF3 gene.

The protein encoded by this gene is one of three (including CSTF1 and CSTF2) cleavage stimulation factors that combine to form the cleavage stimulation factor complex (CSTF). This complex is involved in the polyadenylation and 3' end cleavage of pre-mRNAs. The encoded protein functions as a homodimer and interacts directly with both CSTF1 and CSTF2 in the CSTF complex. Alternative splicing results in multiple transcript variants encoding different isoforms.