CXCL2

Search for
Structures	Swiss-model
Domains	InterPro

chemokine (C-X-C motif) ligand 2
chemokine (C-X-C motif) ligand 2
Identifiers
Symbol	CXCL2
Alt. symbols	SCYB2, GRO2, GROb, MIP-2a, MGSA-b, CINC-2a
NCBI gene	2920
HGNC	4603
OMIM	139110
RefSeq	NM_002089
UniProt	P19875
Other data
Locus	Chr. 4 q21
Structures
Search for
Structures	Swiss-model
Domains	InterPro

CXCL2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1QNK
Identifiers
Aliases	CXCL2, CINC-2a, GRO2, GROb, MGSA-b, MIP-2a, MIP2, MIP2A, SCYB2, C-X-C motif chemokine ligand 2
External IDs	OMIM: 139110; MGI: 108068; HomoloGene: 105490; GeneCards: CXCL2; OMA:CXCL2 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	74,099,196 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	91,040,974 bp
RNA expression pattern
	Top expressed in
	mucosa of paranasal sinus; ; right lobe of liver; ; vena cava; ; saphenous vein; ; cartilage tissue; ; lower lobe of lung; ; beta cell; ; upper lobe of lung; ; upper lobe of left lung; ; gastric mucosa;
	Top expressed in
	endothelial cell of lymphatic vessel; ; left lobe of liver; ; spermatocyte; ; embryo; ; embryo; ; spermatid; ; stroma of bone marrow; ; islet of Langerhans; ; trachea; ; cumulus cell;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; CXCR chemokine receptor binding; cytokine activity; chemokine activity;
Cellular component	extracellular region; extracellular space;
Biological process	chemokine-mediated signaling pathway; response to molecule of bacterial origin; response to lipopolysaccharide; chemotaxis; positive regulation of neutrophil chemotaxis; immune response; regulation of cell population proliferation; cell chemotaxis; defense response; inflammatory response; antimicrobial humoral immune response mediated by antimicrobial peptide; regulation of signaling receptor activity; G protein-coupled receptor signaling pathway; cytokine-mediated signaling pathway; neutrophil chemotaxis; leukocyte chemotaxis; cellular response to lipopolysaccharide;
	Sources:Amigo / QuickGO
Orthologs
	2920
	14825
	ENSG00000081041
	ENSMUSG00000029380
	P19875
	P12850
	NM_002089
	NM_008176
	NP_002080
	NP_032202
	Wikidata
View/Edit Human	View/Edit Mouse

Chemokine (C-X-C motif) ligand 2 (CXCL2) is a small cytokine belonging to the CXC chemokine family that is also called macrophage inflammatory protein 2-alpha (MIP2-alpha), Growth-regulated protein beta (Gro-beta) and Gro oncogene-2 (Gro-2). CXCL2 is 90% identical in amino acid sequence as a related chemokine, CXCL1. This chemokine is secreted by monocytes and macrophages and is chemotactic for polymorphonuclear leukocytes and hematopoietic stem cells. The gene for CXCL2 is located on human chromosome 4 in a cluster of other CXC chemokines. CXCL2 mobilizes cells by interacting with a cell surface chemokine receptor called CXCR2.

CXCL2, like related chemokines, is also a powerful neutrophil chemoattractant and is involved in many immune responses including wound healing, cancer metastasis, and angiogenesis. A study was published in 2013 testing the role of CXCL2, CXCL3, and CXCL1 in the migration of airway smooth muscle cells (ASMCs) migration which plays a significant role in asthma. The results of this study showed that CXCL2 and CXCL3 both help with the mediation of normal and asthmatic ASMC migration through different mechanisms.