Cytochrome b5, type A

CYB5A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2I96
Identifiers
Aliases	CYB5A, CYB5, MCB5, Cytochrome b5, type A, cytochrome b5 type A, METAG
External IDs	OMIM: 613218; MGI: 1926952; HomoloGene: 41475; GeneCards: CYB5A; OMA:CYB5A - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	74,291,973 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	84,897,996 bp
RNA expression pattern
	Top expressed in
	kidney tubule; ; right lobe of liver; ; renal medulla; ; glomerulus; ; pancreatic ductal cell; ; jejunal mucosa; ; metanephric glomerulus; ; body of pancreas; ; gallbladder; ; human kidney;
	Top expressed in
	right kidney; ; olfactory epithelium; ; proximal tubule; ; gallbladder; ; transitional epithelium of urinary bladder; ; human kidney; ; gastrula; ; iris; ; left lobe of liver; ; decidua;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	cytochrome-c oxidase activity; aldo-keto reductase (NADP) activity; metal ion binding; heme binding; enzyme binding;
Cellular component	organelle membrane; integral component of membrane; endoplasmic reticulum membrane; membrane; intracellular membrane-bounded organelle; mitochondrial outer membrane; endoplasmic reticulum; mitochondrion; extracellular exosome; cytoplasm; cytosol;
Biological process	response to cadmium ion; L-ascorbic acid metabolic process; proton transmembrane transport; electron transport chain;
	Sources:Amigo / QuickGO
Orthologs
	1528
	109672
	ENSG00000166347
	ENSMUSG00000024646
	P00167
	P56395
	NM_001190807; NM_001914; NM_148923
	NM_025797; NM_001348159
	NP_001177736; NP_001905; NP_683725
	NP_080073; NP_001335088
	Wikidata
View/Edit Human	View/Edit Mouse

Cytochrome b5, form A (gene name CYB5A), is a human microsomal cytochrome b5.

Cytochrome b5 is a membrane bound hemoprotein which functions as an electron carrier for several membrane bound oxygenases. It has two isoforms produced by alternative splicing. Isoform 1 is bound to the cytoplasmic side of the endoplasmic reticulum. It has a C-terminal transmembrane alpha-helix. Isoform 2 was found in cytoplasm. Defects in CYB5A are the cause of type IV hereditary methemoglobinemia.