Calcipotriol

Calcipotriol
Clinical data
Trade names	Daivonex, others
Other names	calcipotriene (USAN US)
AHFS/Drugs.com	Monograph
MedlinePlus	a608018
License data	US DailyMed: Calcipotriene;
Pregnancy; category	AU: B3;
Routes of; administration	topical
ATC code	D05AX02 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); CA: ℞-only; UK: POM (Prescription only); US: ℞-only;
Pharmacokinetic data
Bioavailability	5 to 6%
Metabolism	Liver
Excretion	Biliary
Identifiers
	IUPAC name (1R,3S,5E)-5-{2-[(1R,3aS,4Z,7aR)-1-[(2R,3E)-5-cyclopropyl-5-hydroxypent-3-en-2-yl]-7a-methyl-octahydro-1H-inden-4-ylidene]ethylidene}-4-methylidenecyclohexane-1,3-diol;
CAS Number	112965-21-6 ;
PubChem CID	5288783;
IUPHAR/BPS	2778;
DrugBank	DB02300 ;
ChemSpider	4450880 ;
UNII	143NQ3779B;
KEGG	D01125 ;
ChEBI	CHEBI:50749 ;
ChEMBL	ChEMBL100918 ;
CompTox Dashboard (EPA)	DTXSID0046648 ;
ECHA InfoCard	100.119.473
Chemical and physical data
Formula	C27H40O3
Molar mass	412.614 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O[C@@H]1CC(\C(=C)[C@@H](O)C1)=C\C=C2/CCC[C@]4([C@H]2CC[C@@H]4[C@@H](/C=C/[C@@H](O)C3CC3)C)C;
	InChI InChI=1S/C27H40O3/c1-17(6-13-25(29)20-8-9-20)23-11-12-24-19(5-4-14-27(23,24)3)7-10-21-15-22(28)16-26(30)18(21)2/h6-7,10,13,17,20,22-26,28-30H,2,4-5,8-9,11-12,14-16H2,1,3H3/b13-6+,19-7+,21-10-/t17-,22-,23-,24+,25-,26+,27-/m1/s1 ; Key:LWQQLNNNIPYSNX-UROSTWAQSA-N ;
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Calcipotriol, also known as calcipotriene and sold under the brand name Dovonex among others, is a synthetic derivative of calcitriol, a form of vitamin D. It is used in the treatment of psoriasis.

It was patented in 1985 and approved for medical use in 1991. It is on the World Health Organization's List of Essential Medicines.

Calcipotriol is also available with the synthetic corticosteroid betamethasone dipropionate as the fixed-dose combination medication calcipotriol/betamethasone dipropionate for the treatment of plaque psoriasis.