Cherokee Turnpike
| Cherokee highlighted in red | |
| Route information | |
| Maintained by Oklahoma Turnpike Authority | |
| Length | 32.8 mi (52.8 km) | 
| Existed | 1991–present | 
| Component highways | US 412 entire length | 
| Major junctions | |
| West end | US 412 west of Locust Grove | 
| East end | US 59 / US 412 west of West Siloam Springs | 
| Location | |
| Country | United States | 
| State | Oklahoma | 
| Counties | Mayes, Delaware | 
| Highway system | |
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The Cherokee Turnpike is a controlled-access toll road in eastern Oklahoma. Opened in 1991, the route is a four-lane freeway carrying US-412 from east of Kansas, Oklahoma, to east of Chouteau, and has a total length of 32.8 miles (52.8 km) and a speed limit of 80 mph (130 km/h).
An alternate route, US-412 Alternate, provides a free but not controlled-access route through the towns bypassed by the Turnpike with only a 55 mph (89 km/h) speed limit.