Cholestasis

Cholestasis
Micrograph showing bile (yellow) stasis in liver tissue, i.e. cholestasis. H&E stain.
SpecialtyGastroenterology

Cholestasis is a condition where the flow of bile from the liver to the duodenum is impaired. The two basic distinctions are:

  • obstructive type of cholestasis, where there is a mechanical blockage in the duct system that can occur from a gallstone or malignancy, and
  • metabolic type of cholestasis, in which there are disturbances in bile formation that can occur because of genetic defects or acquired as a side effect of many medications.

Classification is further divided into acute or chronic and extrahepatic or intrahepatic.

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