Desloratadine

Desloratadine
Clinical data
Trade names	Aerius, others
Other names	Descarboethoxyloratadine
AHFS/Drugs.com	Monograph
MedlinePlus	a602002
License data	US DailyMed: Desloratadine;
Pregnancy; category	AU: B1;
Routes of; administration	By mouth
Drug class	Second-generation antihistamine
ATC code	R06AX27 (WHO) ;
Legal status
Legal status	AU: S2 (Pharmacy medicine); CA: OTC; UK: POM (Prescription only); US: ℞-only; EU: Rx-only / OTC;
Pharmacokinetic data
Bioavailability	Rapidly absorbed
Protein binding	83–87%
Metabolism	UGT2B10, CYP2C8
Metabolites	3-Hydroxydesloratadine
Onset of action	within 1 hour
Elimination half-life	27 hours, 33.7 hours in elderly patients
Duration of action	up to 24 hours
Excretion	40% as conjugated metabolites into urine; Similar amount into the feces
Identifiers
	IUPAC name 8-chloro-6,11-dihydro-11-(4-piperdinylidene)- 5H-benzo[5,6]cyclohepta[1,2-b]pyridine;
CAS Number	100643-71-8 ;
PubChem CID	124087;
IUPHAR/BPS	7157;
DrugBank	DB00967 ;
ChemSpider	110575 ;
UNII	FVF865388R;
KEGG	D03693 ;
ChEBI	CHEBI:291342 ;
ChEMBL	ChEMBL1172 ;
CompTox Dashboard (EPA)	DTXSID1044196 ;
ECHA InfoCard	100.166.554
Chemical and physical data
Formula	C19H19ClN2
Molar mass	310.83 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Clc4cc2c(C(/c1ncccc1CC2)=C3/CCNCC3)cc4;
	InChI InChI=1S/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)13-7-10-21-11-8-13/h1-2,5-6,9,12,21H,3-4,7-8,10-11H2 ; Key:JAUOIFJMECXRGI-UHFFFAOYSA-N ;
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Desloratadine sold under the brand name Aerius among others, is a tricyclic H₁ inverse agonist that is used to treat allergies. It is an active metabolite of loratadine.

It was patented in 1984 and came into medical use in 2001. It was brought to the market in the US by Schering Corporation, later named Schering-Plough.