Claude, Duke of Guise
| Claude de Lorraine | |
|---|---|
| Duke of Guise | |
| Portrait by Jean Clouet | |
| Count / Duke of Guise | |
| Reign | 10 December 1508 – 12 April 1550 | 
| Successor | Francis | 
| Born | 20 October 1496 Château de Custines | 
| Died | 12 April 1550 (aged 53) Château de Joinville | 
| Noble family | Guise | 
| Spouse(s) | |
| Issue | 
 | 
| Father | René II, Duke of Lorraine | 
| Mother | Philippa of Guelders | 
Claude de Lorraine, Duke of Guise (20 October 1496 – 12 April 1550) was a French aristocrat and general. He became the first Duke of Guise in 1528.
He was a highly effective general for the French crown. His children and grandchildren were to lead the Catholic party in the French Wars of Religion.