François, Duke of Guise
| François de Lorraine | |
|---|---|
| Duke of Guise Duke of Aumale Prince de Joinville | |
| Portrait by François Clouet, c. 1550–1560 | |
| Duke of Guise | |
| Reign | 12 April 1550 – 24 February 1563 | 
| Predecessor | Claude | 
| Successor | Henri I | 
| Born | 17 February 1519 Bar-le-Duc, Lorraine, Holy Roman Empire | 
| Died | 24 February 1563 (aged 44) near Orléans, France | 
| Noble family | Guise | 
| Spouse(s) | |
| Issue | Henri I, Duke of Guise Catherine Charles, Duke of Mayenne Louis II, Cardinal of Guise François | 
| Father | Claude, Duke of Guise | 
| Mother | Antoinette de Bourbon | 
François de Lorraine, 2nd Duke of Guise, 1st Prince of Joinville, and 1st Duke of Aumale (17 February 1519 – 24 February 1563), was a French general and statesman. A prominent leader during the Italian War of 1551–1559 and French Wars of Religion, he was assassinated during the siege of Orleans in 1563.