François, Duke of Guise

François de Lorraine
Duke of Guise
Duke of Aumale
Prince de Joinville
Portrait by François Clouet, c.1550–1560
Duke of Guise
Reign12 April 1550 – 24 February 1563
PredecessorClaude
SuccessorHenri I
Born17 February 1519
Bar-le-Duc, Lorraine, Holy Roman Empire
Died24 February 1563(1563-02-24) (aged 44)
near Orléans, France
Noble familyGuise
Spouse(s)
(m. 1548)
IssueHenri I, Duke of Guise
Catherine
Charles, Duke of Mayenne
Louis II, Cardinal of Guise
François
FatherClaude, Duke of Guise
MotherAntoinette de Bourbon

François de Lorraine, 2nd Duke of Guise, 1st Prince of Joinville, and 1st Duke of Aumale (17 February 1519 – 24 February 1563), was a French general and statesman. A prominent leader during the Italian War of 1551–1559 and French Wars of Religion, he was assassinated during the siege of Orleans in 1563.