Derlin-1

DERL1
Identifiers
Aliases	DERL1, DER-1, DER1, derlin 1, derlin-1
External IDs	OMIM: 608813; MGI: 1915069; HomoloGene: 11483; GeneCards: DERL1; OMA:DERL1 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	123,042,302 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	57,755,844 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; islet of Langerhans; ; stromal cell of endometrium; ; tendon of biceps brachii; ; germinal epithelium; ; epithelium of nasopharynx; ; gastrocnemius muscle; ; sperm; ; palpebral conjunctiva; ; tibia;
	Top expressed in
	vestibular membrane of cochlear duct; ; seminal vesicula; ; ciliary body; ; fossa; ; epithelium of lens; ; iris; ; conjunctival fornix; ; transitional epithelium of urinary bladder; ; condyle; ; motor neuron;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; MHC class I protein binding; ubiquitin protein ligase binding; protease binding; ubiquitin-specific protease binding; ATPase binding; signaling receptor activity;
Cellular component	early endosome; VCP-NPL4-UFD1 AAA ATPase complex; integral component of endoplasmic reticulum membrane; Derlin-1-VIMP complex; integral component of membrane; late endosome; membrane; Derlin-1 retrotranslocation complex; endoplasmic reticulum; endoplasmic reticulum membrane; signal recognition particle receptor complex; signal recognition particle;
Biological process	Unfolded Protein Response; endoplasmic reticulum unfolded protein response; ERAD pathway; positive regulation of protein binding; protein transport; protein destabilization; retrograde protein transport, ER to cytosol; viral process; ER-associated misfolded protein catabolic process; protein homooligomerization; positive regulation of protein ubiquitination; establishment of protein localization; ubiquitin-dependent ERAD pathway; response to unfolded protein; protein folding; transmembrane transport; protein ubiquitination; transport; proteasome-mediated ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	79139
	67819
	ENSG00000136986
	ENSMUSG00000022365
	Q9BUN8
	Q99J56
	NM_001134671; NM_024295; NM_001330601; NM_001363963
	NM_024207
	NP_001128143; NP_001317530; NP_077271; NP_001350892
	NP_077169
	Wikidata
View/Edit Human	View/Edit Mouse

Derlin-1 also known as degradation in endoplasmic reticulum protein 1 is a membrane protein that in humans is encoded by the DERL1 gene. Derlin-1 is located in the membrane of the endoplasmic reticulum (ER) and is involved in retrotranslocation of specific misfolded proteins and in ER stress. Derlin-1 is widely expressed in thyroid, fat, bone marrow and many other tissues. The protein belongs to the Derlin-family proteins (also called derlins) consisting of derlin-1, derlin-2 and derlin-3 that are components in the endoplasmic reticulum-associated protein degradation (ERAD) pathway. The derlins mediate degradation of misfolded lumenal proteins within ER, and are named ‘der’ for their ‘Degradation in the ER’. Derlin-1 is a mammalian homologue of the yeast DER1 protein, a protein involved in the yeast ERAD pathway. Moreover, derlin-1 is a member of the rhomboid-like clan of polytopic membrane proteins.

Overexpression of derlin-1 are associated with many cancers, including colon cancer, breast cancer, bladder cancer and non-small cell lung cancer.