DKK2

DKK2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2JTK
Identifiers
Aliases	DKK2, DKK-2, dickkopf WNT signaling pathway inhibitor 2
External IDs	OMIM: 605415; MGI: 1890663; HomoloGene: 8681; GeneCards: DKK2; OMA:DKK2 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	107,283,806 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	131,886,065 bp
RNA expression pattern
	Top expressed in
	skin of thigh; ; skin of hip; ; buccal mucosa cell; ; Achilles tendon; ; testicle; ; Skeletal muscle tissue of rectus abdominis; ; hair follicle; ; thoracic diaphragm; ; right lung; ; muscle of thigh;
	Top expressed in
	vestibular membrane of cochlear duct; ; external carotid artery; ; internal carotid artery; ; iris; ; glomerulus; ; umbilical cord; ; conjunctival fornix; ; saccule; ; gastrula; ; glomerular mesangium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	co-receptor binding; receptor antagonist activity;
Cellular component	extracellular region; extracellular space;
Biological process	positive regulation of canonical Wnt signaling pathway; multicellular organism development; negative regulation of Wnt signaling pathway; Wnt signaling pathway; negative regulation of canonical Wnt signaling pathway; extracellular negative regulation of signal transduction; negative regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	27123
	56811
	ENSG00000155011
	ENSMUSG00000028031
	Q9UBU2
	Q9QYZ8
	NM_014421
	NM_020265
	NP_055236
	NP_064661
	Wikidata
View/Edit Human	View/Edit Mouse

Dickkopf-related protein 2 is a protein in the Dickkopf family that in humans is encoded by the DKK2 gene.

This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway.

It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6).