LRP6

LRP6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3S2K, 3S8V, 3S8Z, 3S94, 3SOB, 3SOQ, 3SOV, 4A0P, 4DG6, 4NM5, 4NM7
Identifiers
Aliases	LRP6, ADCAD2, STHAG7, LDL receptor related protein 6
External IDs	OMIM: 603507; MGI: 1298218; HomoloGene: 1747; GeneCards: LRP6; OMA:LRP6 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	12,267,044 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	134,543,928 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; corpus callosum; ; ventricular zone; ; gonad; ; liver; ; stromal cell of endometrium; ; ganglionic eminence; ; epithelium of colon; ; placenta; ; sural nerve;
	Top expressed in
	ascending aorta; ; aortic valve; ; stroma of bone marrow; ; cumulus cell; ; choroid plexus of fourth ventricle; ; lactiferous gland; ; secondary oocyte; ; extraocular muscle; ; zygote; ; Gonadal ridge;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	low-density lipoprotein particle receptor activity; apolipoprotein binding; protein homodimerization activity; kinase inhibitor activity; frizzled binding; Wnt-protein binding; toxin transmembrane transporter activity; protein binding; coreceptor activity involved in Wnt signaling pathway; identical protein binding; Wnt-activated receptor activity; signaling receptor binding; coreceptor activity involved in canonical Wnt signaling pathway;
Cellular component	integral component of membrane; Wnt-Frizzled-LRP5/6 complex; Wnt signalosome; Golgi apparatus; early endosome membrane; membrane; receptor complex; synapse; extracellular region; cell surface; soma; early endosome; endoplasmic reticulum; caveola; cytoplasmic vesicle; plasma membrane; membrane raft;
Biological process	negative regulation of protein phosphorylation; Wnt signaling pathway involved in somitogenesis; cerebellum morphogenesis; roof of mouth development; dopaminergic neuron differentiation; positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification; regulation of transcription, DNA-templated; endocytosis; receptor-mediated endocytosis involved in cholesterol transport; embryonic pattern specification; convergent extension; negative regulation of protein kinase activity; thalamus development; axis elongation involved in somitogenesis; canonical Wnt signaling pathway involved in neural crest cell differentiation; positive regulation of cytosolic calcium ion concentration; response to peptide hormone; canonical Wnt signaling pathway involved in regulation of cell proliferation; neural crest cell differentiation; positive regulation of DNA-binding transcription factor activity; Wnt signaling pathway; cellular response to cholesterol; neural crest formation; trachea cartilage morphogenesis; positive regulation of transcription, DNA-templated; odontogenesis of dentin-containing tooth; multicellular organism development; midbrain-hindbrain boundary development; neural tube closure; positive regulation of cell cycle; external genitalia morphogenesis; Wnt signaling pathway involved in dorsal/ventral axis specification; pericardium morphogenesis; cerebral cortex development; embryonic retina morphogenesis in camera-type eye; canonical Wnt signaling pathway; negative regulation of protein serine/threonine kinase activity; protein localization to plasma membrane; negative regulation of canonical Wnt signaling pathway; negative regulation of smooth muscle cell apoptotic process; face morphogenesis; primitive streak formation; positive regulation of transcription by RNA polymerase II; chemical synaptic transmission; toxin transport; Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation; positive regulation of canonical Wnt signaling pathway; beta-catenin destruction complex disassembly; midbrain dopaminergic neuron differentiation; gastrulation with mouth forming second; anterior/posterior pattern specification; embryonic limb morphogenesis; midbrain development; bone remodeling; embryonic camera-type eye morphogenesis; bone morphogenesis; branching involved in mammary gland duct morphogenesis; cell-cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	4040
	16974
	ENSG00000070018; ENSG00000281324
	ENSMUSG00000030201
	O75581
	O88572
	NM_002336
	NM_008514
	NP_002327
	NP_032540
	Wikidata
View/Edit Human	View/Edit Mouse

Low-density lipoprotein receptor-related protein 6 is a protein that in humans is encoded by the LRP6 gene. LRP6 is a key component of the LRP5/LRP6/Frizzled co-receptor group that is involved in canonical Wnt pathway.