LRP5

LRP5
Identifiers
Aliases	LRP5, BMND1, EVR1, EVR4, HBM, LR3, LRP-5, LRP7, OPPG, OPS, OPTA1, VBCH2, LDL receptor related protein 5, PCLD4, LRP-7
External IDs	OMIM: 603506; MGI: 1278315; HomoloGene: 1746; GeneCards: LRP5; OMA:LRP5 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	68,449,275 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	3,736,564 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; mucosa of transverse colon; ; ascending aorta; ; apex of heart; ; minor salivary glands; ; Descending thoracic aorta; ; popliteal artery; ; tibial arteries; ; olfactory zone of nasal mucosa; ; right coronary artery;
	Top expressed in
	epithelium of urethra; ; male urethra; ; yolk sac; ; epithelium of male urethra; ; female urethra; ; epithelium of female urethra; ; muscle layer of urethra; ; lip; ; spermatid; ; genital tubercle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	toxin transmembrane transporter activity; protein binding; coreceptor activity involved in Wnt signaling pathway; Wnt-activated receptor activity; coreceptor activity involved in canonical Wnt signaling pathway; Wnt-protein binding;
Cellular component	integral component of membrane; Wnt signalosome; Wnt-Frizzled-LRP5/6 complex; membrane; receptor complex; plasma membrane; endoplasmic reticulum; mitochondrion;
Biological process	regulation of apoptotic process; positive regulation of osteoblast proliferation; regulation of insulin secretion involved in cellular response to glucose stimulus; endocytosis; limb morphogenesis; extracellular matrix-cell signaling; branching involved in mammary gland duct morphogenesis; somatic stem cell population maintenance; bone marrow development; regulation of canonical Wnt signaling pathway; bone morphogenesis; gastrulation with mouth forming second; embryonic digit morphogenesis; positive regulation of DNA-binding transcription factor activity; cell-cell signaling involved in mammary gland development; cholesterol metabolic process; Wnt signaling pathway; negative regulation of osteoblast differentiation; anatomical structure regression; mammary gland duct morphogenesis; regulation of blood pressure; positive regulation of transcription, DNA-templated; multicellular organism development; retina morphogenesis in camera-type eye; vasculature development; apoptotic process involved in blood vessel morphogenesis; positive regulation of mesenchymal cell proliferation; bone remodeling; Wnt signaling pathway involved in dorsal/ventral axis specification; glucose catabolic process; positive regulation of cell population proliferation; retinal blood vessel morphogenesis; canonical Wnt signaling pathway; osteoblast development; negative regulation of protein serine/threonine kinase activity; adipose tissue development; cell migration involved in gastrulation; cholesterol homeostasis; bone development; positive regulation of fat cell differentiation; positive regulation of mitotic nuclear division; retina vasculature morphogenesis in camera-type eye; anterior/posterior pattern specification; positive regulation of transcription by RNA polymerase II; regulation of bone remodeling; beta-catenin destruction complex disassembly; response to peptide hormone; positive regulation of osteoblast differentiation; toxin transport; Norrin signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	4041
	16973
	ENSG00000162337
	ENSMUSG00000024913
	O75197
	Q91VN0
	NM_001291902; NM_002335
	NM_008513
	NP_001278831; NP_002326
	NP_032539
	Wikidata
View/Edit Human	View/Edit Mouse

Low-density lipoprotein receptor-related protein 5 is a protein that in humans is encoded by the LRP5 gene. LRP5 is a key component of the LRP5/LRP6/Frizzled co-receptor group that is involved in canonical Wnt pathway. Mutations in LRP5 can lead to considerable changes in bone mass. A loss-of-function mutation causes osteoporosis pseudoglioma syndrome with a decrease in bone mass, while a gain-of-function mutation causes drastic increases in bone mass.