DLK1

DLK1
Identifiers
Aliases	DLK1, DLK, DLK-1, Delta1, FA1, PREF1, Pref-1, ZOG, pG2, AW742678, DlkI, Ly107, Peg9, SCP1, delta like non-canonical Notch ligand 1
External IDs	OMIM: 176290; MGI: 94900; HomoloGene: 2846; GeneCards: DLK1; OMA:DLK1 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	100,738,224 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	109,429,262 bp
RNA expression pattern
	Top expressed in
	right adrenal cortex; ; left adrenal cortex; ; anterior pituitary; ; cartilage tissue; ; beta cell; ; glutes; ; left ovary; ; placenta; ; parotid gland; ; body of tongue;
	Top expressed in
	yolk sac; ; adrenal gland; ; Hypothalamus; ; placenta; ; neural tube; ; Mesencephalon; ; genital tubercle; ; limb; ; rhombencephalon; ; tail of embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; molecular function;
Cellular component	integral component of membrane; membrane; extracellular space; cytoplasm;
Biological process	cell differentiation; negative regulation of Notch signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	8788
	13386
	ENSG00000185559
	ENSMUSG00000040856
	P80370
	Q09163
	NM_001032997; NM_003836; NM_001317172
	NM_001190703; NM_001190704; NM_001190705; NM_010052
	NP_001304101; NP_003827; NP_003827.3
	NP_001177632; NP_001177633; NP_001177634; NP_034182
	Wikidata
View/Edit Human	View/Edit Mouse

Protein delta homolog 1, delta like non-canonical Notch ligand 1, fetal antigen 1 or preadipocyte factor 1 is a protein that in humans is encoded by the DLK1 gene.

It is expressed as a transmembrane protein, but a soluble form cleaved off by ADAM17 is active in inhibiting adipogenesis, the differentiation of pre-adipocytes into adipocytes.

It is a member of the EGF-like family of homeotic proteins.

Part of the Dlk1-DIO3 imprinting control region, this gene is one involved in the epigenetic process that causes a subset of genes to be regulated based on their parental origin.

Such imprinted genes are required for the formation of the placenta as well as the development of cellular lineages such as those derived from the mesoderm and ectoderm.