DNAJA3

DNAJA3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CTT, 2DN9
Identifiers
Aliases	DNAJA3, HCA57, TID1, hTID-1, DnaJ heat shock protein family (Hsp40) member A3
External IDs	OMIM: 608382; MGI: 1933786; HomoloGene: 36170; GeneCards: DNAJA3; OMA:DNAJA3 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	4,456,775 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	4,525,559 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; skeletal muscle tissue; ; muscle of thigh; ; right adrenal gland; ; right adrenal cortex; ; right lobe of liver; ; left adrenal gland; ; left ventricle; ; left adrenal cortex; ; apex of heart;
	Top expressed in
	interventricular septum; ; Ileal epithelium; ; extensor digitorum longus muscle; ; brown adipose tissue; ; right kidney; ; plantaris muscle; ; soleus muscle; ; digastric muscle; ; myocardium of ventricle; ; sternocleidomastoid muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	interferon-gamma receptor binding; heat shock protein binding; GTPase regulator activity; unfolded protein binding; transcription factor binding; metal ion binding; NF-kappaB binding; protein binding; ATP binding; protein kinase binding; Hsp70 protein binding;
Cellular component	cytoplasm; cytosol; postsynaptic membrane; I-kappaB/NF-kappaB complex; intracellular membrane-bounded organelle; membrane; neuromuscular junction; plasma membrane; synapse; cell junction; mitochondrial matrix; mitochondrion; actin filament; extrinsic component of plasma membrane; mitochondrial nucleoid; IkappaB kinase complex; nucleus;
Biological process	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of interferon-gamma-mediated signaling pathway; T cell differentiation in thymus; response to interferon-gamma; negative regulation of protein kinase activity; small GTPase mediated signal transduction; protein stabilization; mitochondrion organization; negative regulation of apoptotic process; activation-induced cell death of T cells; response to heat; negative regulation of transcription by RNA polymerase II; mitochondrial DNA replication; negative regulation of I-kappaB kinase/NF-kappaB signaling; protein folding; neuromuscular junction development; positive regulation of T cell proliferation; positive regulation of apoptotic process; negative regulation of programmed cell death; regulation of catalytic activity; negative regulation of NF-kappaB transcription factor activity; activation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of protein ubiquitination; negative regulation of cell population proliferation; apoptotic process; skeletal muscle acetylcholine-gated channel clustering;
	Sources:Amigo / QuickGO
Orthologs
	9093
	83945
	ENSG00000276726; ENSG00000103423
	ENSMUSG00000004069
	Q96EY1; Q53G26
	Q99M87
	NM_005147; NM_001135110; NM_001286516
	NM_001135112; NM_023646
	NP_001128582; NP_001273445; NP_005138; NP_005138.3
	NP_001128584; NP_076135
	Wikidata
View/Edit Human	View/Edit Mouse

DnaJ homolog subfamily A member 3, mitochondrial, also known as Tumorous imaginal disc 1 (TID1), is a protein that in humans is encoded by the DNAJA3 gene on chromosome 16. This protein belongs to the DNAJ/Hsp40 protein family, which is known for binding and activating Hsp70 chaperone proteins to perform protein folding, degradation, and complex assembly. As a mitochondrial protein, it is involved in maintaining membrane potential and mitochondrial DNA (mtDNA) integrity, as well as cellular processes such as cell movement, growth, and death. Furthermore, it is associated with a broad range of diseases, including neurodegenerative diseases, inflammatory diseases, and cancers.