Drosha

DROSHA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2KHX, 5B16
Identifiers
Aliases	DROSHA, ETOHI2, HSA242976, RANSE3L, RN3, RNASE3L, RNASEN, drosha ribonuclease III
External IDs	OMIM: 608828; MGI: 1261425; HomoloGene: 8293; GeneCards: DROSHA; OMA:DROSHA - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	31,532,196 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	12,935,377 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; ventricular zone; ; germinal epithelium; ; Brodmann area 23; ; right hemisphere of cerebellum; ; ganglionic eminence; ; middle temporal gyrus; ; sural nerve; ; epithelium of colon; ; anterior pituitary;
	Top expressed in
	primitive streak; ; Paneth cell; ; otolith organ; ; fossa; ; utricle; ; condyle; ; substantia nigra; ; Rostral migratory stream; ; aortic valve; ; ascending aorta;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ribonuclease III activity; protein homodimerization activity; lipopolysaccharide binding; metal ion binding; endoribonuclease activity; protein binding; nuclease activity; endonuclease activity; hydrolase activity; RNA binding; DEAD/H-box RNA helicase binding; SMAD binding; R-SMAD binding; primary miRNA binding; double-stranded RNA binding;
Cellular component	nucleoplasm; microprocessor complex; nucleolus; nucleus; plasma membrane; focal adhesion; postsynaptic density;
Biological process	RNA processing; ribosome biogenesis; nucleic acid phosphodiester bond hydrolysis; rRNA catabolic process; positive regulation of gene expression; defense response to Gram-negative bacterium; regulation of miRNA metabolic process; primary miRNA processing; regulation of gene expression; defense response to Gram-positive bacterium; RNA phosphodiester bond hydrolysis, endonucleolytic; regulation of regulatory T cell differentiation; RNA phosphodiester bond hydrolysis; regulation of inflammatory response; miRNA metabolic process; gene silencing; production of siRNA involved in RNA interference; pre-miRNA processing;
	Sources:Amigo / QuickGO
Orthologs
	29102
	14000
	ENSG00000113360
	ENSMUSG00000022191
	Q9NRR4
	Q5HZJ0
	NM_001100412; NM_013235; NM_001382508
	NM_001130149; NM_026799
	NP_001093882; NP_037367; NP_001369437
	NP_001123621; NP_081075
	Wikidata
View/Edit Human	View/Edit Mouse

Drosha is a Class 2 ribonuclease III enzyme that in humans is encoded by the DROSHA (formerly RNASEN) gene. It is the primary nuclease that executes the initiation step of miRNA processing in the nucleus. It works closely with DGCR8 and in correlation with Dicer. It has been found significant in clinical knowledge for cancer prognosis. and HIV-1 replication.