DTX3L

DTX3L
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3PG6
Identifiers
Aliases	DTX3L, BBAP, deltex 3 like, E3 ubiquitin ligase, deltex E3 ubiquitin ligase 3L, RNF143
External IDs	OMIM: 613143; MGI: 2656973; HomoloGene: 51375; GeneCards: DTX3L; OMA:DTX3L - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	122,575,203 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	35,759,521 bp
RNA expression pattern
	Top expressed in
	mucosa of ileum; ; pancreatic ductal cell; ; lower lobe of lung; ; decidua; ; epithelium of nasopharynx; ; pericardium; ; mucosa of paranasal sinus; ; germinal epithelium; ; pylorus; ; human penis;
	Top expressed in
	mesenteric lymph nodes; ; jejunum; ; seminal vesicula; ; submandibular gland; ; blood; ; lumbar spinal ganglion; ; ileum; ; cervix; ; subcutaneous adipose tissue; ; thymus;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; metal ion binding; ubiquitin-protein transferase activity; transferase activity; enzyme inhibitor activity; enzyme activator activity; enzyme binding; histone binding; ubiquitin-like protein ligase binding; STAT family protein binding;
Cellular component	cytoplasm; nucleus; nucleoplasm; cytosol; early endosome; lysosome; lysosomal membrane; endosome; membrane; early endosome membrane; protein-containing complex;
Biological process	histone monoubiquitination; double-strand break repair; DNA repair; protein ubiquitination; cellular response to DNA damage stimulus; protein polyubiquitination; positive regulation of defense response to virus by host; endosome to lysosome transport; positive regulation of protein binding; histone H2A ubiquitination; histone H2B ubiquitination; positive regulation of chromatin binding; positive regulation of transcription, DNA-templated; negative regulation of ubiquitin-protein transferase activity; protein autoubiquitination; protein K48-linked ubiquitination; positive regulation of protein localization to nucleus; positive regulation of NAD+ ADP-ribosyltransferase activity; positive regulation of protein localization to early endosome; positive regulation of receptor catabolic process; positive regulation of double-strand break repair via nonhomologous end joining; immune system process; protein transport; innate immune response; defense response to virus; chromatin organization; ubiquitin-dependent protein catabolic process; Notch signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	151636
	209200
	ENSG00000163840
	ENSMUSG00000049502
	Q8TDB6
	Q3UIR3
	NM_138287
	NM_001013371
	NP_612144
	NP_001013389
	Wikidata
View/Edit Human	View/Edit Mouse

Deltex E3 ubiquitin ligase 3L is a protein that in humans is encoded by the DTX3L gene. It functions as an ubiquitin ligase (E3), and is over-expressed in chemotherapy-resistant lymphomas. It is a member of the DTX family of proteins. Among other roles it has a function in DNA damage repair.

It was discovered through two-hybrid screening during a search for binding partners of PARP9 (formerly BAL), a gene related to the risk of B-cell lymphoma. and was originally named BBAP (B-lymphoma- and BAL-associated protein).

DTX3L and PARP9 are both located in the same 48kB region of the genome, and are both regulated by a IFN-γ-responsive bidirectional promoter. DTX3L has a long N-terminus domain distinct from other DTX-family proteins that allows it form dimers with itself and other proteins. It has been found to be up-regulated by METTL3.