DUSP2

DUSP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1M3G
Identifiers
Aliases	DUSP2, PAC-1, PAC1, dual specificity phosphatase 2
External IDs	OMIM: 603068; MGI: 101911; HomoloGene: 3255; GeneCards: DUSP2; OMA:DUSP2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	96,145,440 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	127,180,296 bp
RNA expression pattern
	Top expressed in
	seminal vesicula; ; granulocyte; ; lymph node; ; mucosa of urinary bladder; ; monocyte; ; spleen; ; testicle; ; gallbladder; ; bone marrow cells; ; appendix;
	Top expressed in
	mesenteric lymph nodes; ; thymus; ; spleen; ; trachea; ; blood; ; granulocyte; ; embryo; ; lip; ; tibiofemoral joint; ; bone marrow;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein tyrosine phosphatase activity; phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; protein tyrosine/threonine phosphatase activity; protein binding; phosphoprotein phosphatase activity; hydrolase activity; protein tyrosine/serine/threonine phosphatase activity; mitogen-activated protein kinase binding;
Cellular component	nucleus; nuclear membrane; cytoplasm;
Biological process	protein dephosphorylation; endoderm formation; dephosphorylation; peptidyl-tyrosine dephosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	1844
	13537
	ENSG00000158050
	ENSMUSG00000027368
	Q05923
	Q05922
	NM_004418
	NM_010090
	NP_004409
	NP_034220
	Wikidata
View/Edit Human	View/Edit Mouse

Dual specificity protein phosphatase 2 is an enzyme that in humans is encoded by the DUSP2 gene.

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation.

Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1 and ERK2, is predominantly expressed in hematopoietic tissues, and is localized in the nucleus.