Deoxypyridinoline
| Names | |
|---|---|
| Systematic IUPAC name
(2R)-6-{3-[(3S)-3-Amino-3-carboxypropyl]-4-[(2S)-2-amino-3-carboxyethyl]-5-hydroxypyridin-1-ium-1-yl}hexanoate | |
| Identifiers | |
| ChemSpider | |
PubChem CID |
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| UNII | |
CompTox Dashboard (EPA) |
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| Properties | |
| C18H28N4O7 | |
| Molar mass | 412.43752 g mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references | |
Deoxypyridinoline, also called D-Pyrilinks, Pyrilinks-D, or deoxyPYD, is one of two pyridinium cross-links that provide structural stiffness to type I collagen found in bones. It is excreted unmetabolized in urine and is a specific marker of bone resorption and osteoclastic activity. It is measured in urine tests and is used along with other bone markers such as alkaline phosphatase, osteocalcin, and N-terminal telopeptide to diagnose bone diseases such as postmenopausal osteoporosis, bone metastasis, and Paget's disease, furthermore, it has been useful in monitoring treatments that contain bone-active agents such as estrogens and bisphosphonates.
Certain studies have attempted to generate a standardization of Deoxypyridinoline via an individual molar absorptivity value at acid and neutrality pH. The result was 5160 and 5290 L mol−1 cm−1 respectively.