Duloxetine
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| Pronunciation | /duːˈlɑːksəˌtin/ doo-LAHK-sə-teen |
| Trade names | Cymbalta, others |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a604030 |
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| Routes of administration | By mouth |
| Drug class | Serotonin–norepinephrine reuptake inhibitor |
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| Pharmacokinetic data | |
| Bioavailability | ~ 50% (32% to 80%) |
| Protein binding | ~ 95% |
| Metabolism | Liver, two P450 isozymes, CYP2D6 and CYP1A2 |
| Elimination half-life | 10–12 h |
| Excretion | 70% in urine, 20% in feces |
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| ECHA InfoCard | 100.116.825 |
| Chemical and physical data | |
| Formula | C18H19NOS |
| Molar mass | 297.42 g·mol−1 |
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Duloxetine, sold under the brand name Cymbalta among others, is a medication used to treat major depressive disorder, generalized anxiety disorder, obsessive–compulsive disorder, fibromyalgia, neuropathic pain, central sensitization, and other types of chronic pain. It is taken by mouth.
Duloxetine is a serotonin–norepinephrine reuptake inhibitor (SNRI). The precise mechanism for its antidepressant and anxiolytic effects is not known.
Common side effects include dry mouth, nausea, constipation, loss of appetite, drowsiness, sexual problems, and increased sweating. Severe side effects include an increased risk of suicide, serotonin syndrome, mania, and liver problems. Antidepressant withdrawal syndrome may occur if stopped. Use during the later part of pregnancy may increase the risk of bleeding or cause complications for the fetus.
Duloxetine was approved for medical use in the United States and the European Union in 2004. It is available as a generic medication. In 2022, it was the 31st most commonly prescribed medication in the United States, with more than 18 million prescriptions.