Ephrin A5

EFNA5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2X11, 3MX0, 4BK5, 4BKA, 4L0P, 4M4R
Identifiers
Aliases	EFNA5, AF1, EFL5, EPLG7, GLC1M, LERK7, RAGS, ephrin A5
External IDs	OMIM: 601535; MGI: 107444; HomoloGene: 1482; GeneCards: EFNA5; OMA:EFNA5 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	107,670,937 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	63,188,312 bp
RNA expression pattern
	Top expressed in
	hair follicle; ; Brodmann area 23; ; middle temporal gyrus; ; primary visual cortex; ; germinal epithelium; ; synovial joint; ; parietal pleura; ; nipple; ; endothelial cell; ; pancreatic ductal cell;
	Top expressed in
	superior cervical ganglion; ; utricle; ; external carotid artery; ; ciliary body; ; internal carotid artery; ; iris; ; arcuate nucleus; ; hand; ; epithelium of lens; ; epithelium of stomach;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	neurotrophin TRKC receptor binding; transmembrane receptor protein tyrosine kinase activator activity; neurotrophin TRKA receptor binding; ephrin receptor binding; chemorepellent activity; neurotrophin TRKB receptor binding; protein binding;
Cellular component	membrane; plasma membrane; anchored component of external side of plasma membrane; caveola; anchored component of membrane; basement membrane; adherens junction; cell periphery; GABA-ergic synapse;
Biological process	positive regulation of synapse assembly; apoptotic process; cell differentiation; regulation of insulin secretion involved in cellular response to glucose stimulus; positive regulation of protein phosphorylation; negative chemotaxis; regulation of actin cytoskeleton organization; regulation of GTPase activity; ephrin receptor signaling pathway; regulation of microtubule cytoskeleton organization; positive regulation of collateral sprouting; nervous system development; multicellular organism development; regulation of cell-cell adhesion; positive regulation of peptidyl-tyrosine phosphorylation; regulation of focal adhesion assembly; regulation of cell morphogenesis; collateral sprouting; negative regulation of substrate adhesion-dependent cell spreading; retinal ganglion cell axon guidance; cellular response to follicle-stimulating hormone stimulus; cellular response to forskolin; activation of transmembrane receptor protein tyrosine kinase activity; axon guidance; synaptic membrane adhesion;
	Sources:Amigo / QuickGO
Orthologs
	1946
	13640
	ENSG00000184349
	ENSMUSG00000048915
	P52803
	O08543
	NM_001962
	NM_010109; NM_207654
	NP_001953
	NP_034239; NP_997537
	Wikidata
View/Edit Human	View/Edit Mouse

Ephrin A5 is a protein that in humans is encoded by the EFNA5 gene.

Ephrin A5 is a glycosylphosphatidylinositol (GPI)-anchored protein of the ephrin-A subclass of ephrin ligands that binds to the EphA subclass of Eph receptors. Ephrin A5 has also been shown to bind to the EphB2 receptor.